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实验性药物可成为新减肥方法

  1. 实验性药物
  2. 疗法
  3. 白色脂肪
  4. 肥胖
  5. 褐色脂肪

来源:生物谷 2015-03-10 11:33

近日,在圣地亚哥举办的第97届内分泌学会会议上,休斯敦卫理公会研究所(Houston Methodist Research Institute)的研究人员通过研究表示,一种实验性药物或可促进小鼠脂肪和体重下降。这种药物名为GC-1,其可以加速机体脂肪细胞代谢燃烧脂肪。

2015年3月10日 讯 /生物谷BIOON/ --近日,在圣地亚哥举办的第97届内分泌学会会议上,休斯敦卫理公会研究所(Houston Methodist Research Institute)的研究人员通过研究表示,一种实验性药物或可促进小鼠脂肪和体重下降。这种药物名为GC-1,其可以加速机体脂肪细胞代谢燃烧脂肪。

研究者Kevin Phillips博士表示GC-1可以明显增加小鼠机体的代谢率,从本质上将有害的白色脂肪(white fat)转化成为有益的褐色脂肪(brown fat),白色脂肪往往那个可以储存过多热量,而且其和糖尿病及代谢性疾病的发病直接相关,而褐色脂肪可以燃烧掉更多能量。

数年以前科学家们就认为仅仅在动物和人类的婴儿体内才存在这种可以燃烧能量的有益褐色脂肪,如今研究者发现,在成年人机体中也存在这种褐色脂肪,但其随着时间延长就会慢慢失去燃烧脂肪的能力。一些已经发表的研究成果表示,那些拥有较多褐色脂肪的个体往往患肥胖和糖尿病的风险较低,而如今研究者也正在致力于将白色脂肪转化为褐色脂肪的研究。

研究者表示,GC-1可以通过激活机体的甲状腺激素受体来将白色脂肪转化为褐色脂肪,甲状腺激素受体在调节机体代谢中扮演着重要角色,其可以将食物转化成为能量,同时还可以帮助进行机体的适应性发热作用,即机体将过度的能量转化为热释放出去。如今研究者已经用这种名为GC-1的药物在成千上万只小鼠中进行了测试,研究者给予肥胖、遗传性肥胖及饮食诱导的糖尿病小鼠每日进行GC-1服用。

结果显示,在大约两周后,遗传性肥胖小鼠的体重降低了,而且其机体的脂肪量下降了超过50%,进行治疗的小鼠同时也表现出了抗糖尿病的效应,比如其胰岛素敏感性得到了明显改善,而且饮食诱导的肥胖小鼠也表现出了类似的改善效果。研究者表示,GC-1还可以诱导小鼠离体的脂肪细胞进行适应性发热作用,本文研究表明GC-1或许可以作为一种新型的褐色脂肪制剂来帮助开发治疗肥胖和代谢性疾病的疗法。

目前GC-1还没有在人类机体中进行体重减轻的测试,但其正在进行降胆固醇的测试,研究者希望通过后期的测试来在人类机体中证实GC-1的作用效果,从而为开发治疗肥胖和代谢性障碍的患者提供帮助和希望。(生物谷Bioon.com)

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Known as GC-1, the drug reportedly speeds up metabolism, or burning off, of fat cells.

"GC-1 dramatically increases the metabolic rate, essentially converting white fat, which stores excess calories and is associated with obesity and metabolic disease, into a fat like calorie-burning brown fat," said study author Kevin Phillips, PhD, a researcher at Houston Methodist Research Institute, Houston.

Until several years ago, scientists thought that only animals and human infants have energy-burning, "good" brown fat.

"It is now clear," Phillips said, "that human adults do have brown fat, but appear to lose its calorie-burning activity over time."

White adipose tissue, or fat, becomes a "metabolic villain," as Phillips called it, when the body has too much of it. Some published research shows that people who have more brown fat have a reduced risk of obesity and diabetes. Researchers are now working on ways to "brown" white fat, or convert it into brown fat.

GC-1 works, according to Phillips, by activating the receptors for thyroid hormone, which play a role in regulating metabolism--the body's conversion of food into energy. Thyroid hormone receptors also help with adaptive thermogenesis, in which the body converts excess energy (calories and fat) to heat.

Phillips said he and other researchers at Houston Methodist Research Institute have tested the drug in hundreds of mice, with partial research funding from the National Institutes of Health. Obese mice, both genetically obese and those with diet-induced obesity, received GC-1 treatment daily.

Genetically obese mice lost weight and more than 50 percent of their fat mass in approximately two weeks, Phillips reported. Treated mice also showed antidiabetic effects, such as a sixfold improvement or better in insulin sensitivity (how well the body clears glucose from the bloodstream). He said mice with diet-induced obesity experienced similar improvements.....

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