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首页 » 生物研究 » The FASEB J:寒冷或可将有害脂肪细胞转化成为有益脂肪细胞

The FASEB J:寒冷或可将有害脂肪细胞转化成为有益脂肪细胞

来源:生物谷 2015-01-07 09:50

2015年1月7日 讯 /生物谷BIOON/ --白色脂肪和棕色脂肪在机体代谢中的角色已经非常清楚,但近日,一项发表于国际杂志the FASEB Journal上的研究论文中,来自韦恩州立大学(Wayne State University)的研究人员通过研究发现,两种脂肪或许可以互相转化,这仅仅依赖于温度就可以实现,尤其是在低温条件下或许可以将不健康的白色脂肪转化成为健康的棕色脂肪。

文章中,研究者James G. Granneman表示,脂肪细胞会采取一系列的代谢表型,这主要依赖于机体的生理条件和其所在的位置,我们的长期目标就是去揭示脂肪细胞的代谢的复杂性来帮助开发和脂肪异常相关的代谢疾病,比如2型糖尿病。

这项研究中,研究人员利用新型技术,在小鼠模型暴露于寒冷之前对其机体中未分化的前体细胞或已分化的脂肪细胞进行标记,随后将小鼠置于野外低温压力条件下,研究者开始追踪是否小鼠机体中的白色脂肪细胞会转变成为棕色脂肪细胞,结果显示,在典型的棕色脂肪组织中,标记的前体细胞会发生分裂转变成为新型的棕色脂肪细胞,而该过程需要组织中神经的激活,并且需要通过特殊的受体来参与。

相反,在白色脂肪组织中出现的大部分棕色脂肪细胞就会被成熟脂肪细胞标记物所标记,本文研究揭示,在处于低温压力前,大约有30%的即将成为白色脂肪细胞的细胞都会快速开启棕色脂肪细胞转变程序从而转变成为棕色脂肪细胞。

最后杂志主编Gerald Weissmann博士表示,如果我们想加快机体的新陈代谢,那么在冬天就不要扔掉棉衣。本文的研究亮点在于阐明了白色脂肪细胞在寒冷条件下可以向棕色脂肪细胞转换,而寒冷环境或许可以诱发某种细胞机制,进而来促进棕色脂肪细胞的产生,这种控制脂肪转换的开关或许会是以后开发治疗肥胖相关疾病的新型疗法的一个靶点。(生物谷Bioon.com)

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Cellular origins of cold-induced brown adipocytes in adult mice

Yun-Hee Lee*, Anelia P. Petkova*, Anish A. Konkar*,1 and James G. Granneman*,2

This work investigated how cold stress induces the appearance of brown adipocytes (BAs) in brown and white adipose tissues (WATs) of adult mice. In interscapular brown adipose tissue (iBAT), cold exposure increased proliferation of endothelial cells and interstitial cells expressing platelet-derived growth factor receptor, α polypeptide (PDGFRα) by 3- to 4-fold. Surprisingly, brown adipogenesis and angiogenesis were largely restricted to the dorsal edge of iBAT. Although cold stress did not increase proliferation in inguinal white adipose tissue (ingWAT), the percentage of BAs, defined as multilocular adipocytes that express uncoupling protein 1, rose from undetectable to 30% of total adipocytes. To trace the origins of cold-induced BAs, we genetically tagged PDGFRα+ cells and adipocytes prior to cold exposure, using Pdgfra-Cre recombinase estrogen receptor T2 fusion protein (CreERT2) and adiponectin-CreERT2, respectively. In iBAT, cold stress triggered the proliferation and differentiation of PDGFRα+ cells into BAs. In contrast, all newly observed BAs in ingWAT (5207 out of 5207) were derived from unilocular adipocytes tagged by adiponectin-CreERT2-mediated recombination. Surgical denervation of iBAT reduced cold-induced brown adipogenesis by >85%, whereas infusion of norepinephrine (NE) mimicked the effects of cold in warm-adapted mice. NE-induced de novo brown adipogenesis in iBAT was eliminated in mice lacking β1-adrenergic receptors. These observations identify a novel tissue niche for brown adipogenesis in iBAT and further define depot-specific mechanisms of BA recruitment.—Lee, Y.-H., Petkova, A. P., Konkar, A. A., Granneman, J. G. Cellular origins of cold-induced brown adipocytes in adult mice.

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