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Sleep:开发出诊断儿童睡眠障碍的新型测量技术

来源:生物谷 2014-12-30 10:27

2014年12月30日 讯 /生物谷BIOON/ --发表在国际杂志Sleep上的一项研究中,来自阿德莱德大学的科学家通过研究阐明了儿童睡眠的复杂性,相关研究或为改善睡眠相关呼吸障碍儿童的诊断提供思路和帮助。

文章中,研究者Coussens表示,我们进行了调查来揭示如何精确测定儿童睡眠障碍的水平,目的在于阐明是否患儿需要进行疗法治疗;优质睡眠对于儿童相当重要,尤其是那些处于发育关键阶段的儿童,其可以影响儿童大脑的健康,而且在儿童的语言发育中扮演着重要角色,较差的睡眠治疗会引发IQ下降以及校园表现力下降等,以至于最终影响儿童长大后的一生的生活。

从20世纪90年来以来研究者们已经找到了儿童睡眠障碍的一个很好的指数,但是其很难测定,因为儿童的睡眠和成人睡眠并不相同;对于成人而言,许多睡眠障碍迹象都很明显,而儿童常常处于“睡眠保存”的模式,这就使其容易出现深睡眠,但是研究者并不清楚该过程中到底发生着什么。

研究人员对92名小学学龄儿童进行研究,测定了这些儿童中超过30种不同的睡眠参数,包括肌肉运动、呼吸、眼部活动及大脑处理过程的改变情况等,研究者发现,在睡眠儿童机体中只有运动的方式会被干扰,这与儿童是否患睡眠障碍无关,因此这或许就是引发儿童睡眠潜在障碍的一个标志。

基于本项研究,研究人员开发了一种测定方法,其可以帮助研究者将儿童精确分为有或无睡眠相关呼吸问题的两个小组;而这种新型测定方法也可以用来指示儿童睡眠问题的严重性,从而为开发治疗睡眠障碍的新型靶向性疗法提供帮助。(生物谷Bioon.com)

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Movement Distribution: A New Measure of Sleep Fragmentation in Children with Upper Airway Obstruction

Scott Coussens, BSc(Hons)1,2; Mathias Baumert, PhD3,4; Mark Kohler, PhD4; James Martin, MD2; Declan Kennedy, MD2,4; Kurt Lushington, PhD5; David Saint, PhD1; Yvonne Pamula, PhD2

Study Objectives: To develop a measure of sleep fragmentation in children with upper airway obstruction based on survival curve analysis of sleep continuity. Design: Prospective repeated measures. Setting: Hospital sleep laboratory. Participants: 92 children aged 3.0 to 12.9 years undergoing 2 overnight polysomnographic (PSG) sleep studies, 6 months apart. Subjects were divided into 3 groups based on their obstructive apnea and hypopnea index (OAHI) and other upper airway obstruction (UAO) symptoms: primary snorers (PS; n = 24, OAHI < 1), those with obstructive sleep apnea syndrome (OSAS; n = 20, OAHI ≥ 1) and non-snoring controls (C; n = 48, OAHI < 1). Interventions: Subjects in the PS and OSAS groups underwent tonsillectomy and adenoidectomy between PSG assessments. Measurements and Results: Post hoc measures of movement and contiguous sleep epochs were exported and analyzed using Kaplan-Meier estimates of survival to generate survival curves for the 3 groups. Statistically significant differences were found between these group curves for sleep continuity (P < 0.05) when using movement events as the sleep fragmenting event, but not if stage 1 NREM sleep or awakenings were used. Conclusion: Using conventional indices of sleep fragmentation in survival curve analysis of sleep continuity does not provide a useful measure of sleep fragmentation in children with upper airway obstruction. However, when sleep continuity is defined as the time between gross body movements, a potentially useful clinical measure is produced. Citation: Coussens S, Baumert M, Kohler M, Martin J, Kennedy D, Lushington K, Saint D, Pamula Y. Movement distribution: a new measure of sleep fragmentation in children with upper airway obstruction. SLEEP 2014;37(12):2025-2034.

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