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Diabetes Obes Metabo:二甲双胍对肥胖儿童的影响

来源:生物谷 2014-12-25 10:51

2014年12月24日讯 /生物谷BIOON/ --根据公布在Diabetes, Obesity and Metabolism杂志上一则研究提示,对于肥胖儿童,二甲双胍似乎可以降低饥饿感和增加饱腹感觉。

美国国立卫生研究院Mopelola A. Adeyemo和他的同事对年龄在6至12岁的100名肥胖高胰岛素血症儿童,进行了一项为期6个月的随机、双盲、安慰剂对照试验,以评估二甲双胍对体重和能量平衡的影响,共84名儿童数据可用(45名二甲双胍治疗者和39名安慰剂治疗)。

研究人员发现,二甲双胍治疗与平均能量摄入基线显著减少相关,二甲双胍显著降低饥饿率,并增加了饱腹感(P = 0.013和0.01)。总之,我们发现,二甲双胍治疗的减肥效果可能与它减少肥胖高胰岛素血症儿童能量摄入的能力相关。

因此二甲双胍可以作为饮食,运动和行为治疗的辅助,对于肥胖儿童的控制是非常有用的。(生物谷Bioon.com)

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doi:10.1111/dom.12426
PMC:
PMID:

Effects of Metformin on Energy Intake and Satiety in Obese Children

Mopelola A. Adeyemo MPH, et al.

Aims
Metformin's ability to promote weight loss is believed to be at least partly attributable to decreased energy consumption. There are few data regarding the effects of metformin on energy intake in children. We therefore investigated metformin's effects on appetite and energy intake in obese hyperinsulinemic children.

Materials and Methods
We conducted a 6-month randomized, double-blind, placebo-controlled trial to evaluate the effects of metformin 1000mg BID on body weight and energy balance in 100 obese hyperinsulinemic children aged 6-12y. Subjects ate ad libitum from standardized food arrays on two separate occasions before, and then again after, 6 months of study medication. The first test meal was consumed after an overnight fast. The second was preceded by a pre-meal load. For each test meal, energy intake was recorded, and subjects completed scales of hunger, fullness, and desire to eat.

Results
Data from the meal studies at baseline and after treatment with study medication were available for 84 children (45 metformin-treated and 39 placebo-treated). Compared with placebo, metformin treatment elicited significant reductions from baseline in adjusted mean energy intake after the pre-meal load (metformin: 104.7±83.8kcal vs. placebo: +144.2±96.9kcal; p?=0.034) independent of changes in body composition. Metformin also significantly decreased ratings of hunger (1.5±5.6 vs. +18.6±6.3; p=0.013) and increased ratings of fullness (+10.1±6.2 vs. -12.8±7.0; p?=0.01) following the pre-meal load.

Conclusions
These data suggest that decreased perceived hunger resulting in diminished food intake are among the mechanisms by which metformin treatment reduces body weight in overweight, hyperinsulinemic children.

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