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Cancer:骨质疏松症治疗药物有助预防子宫内膜癌

来源:生物谷 2014-12-23 10:38

2014年12月23日讯 /生物谷BIOON/ --一项新的分析表明,使用双磷酸盐类药物(此类药物通常用于治疗骨质疏松症和其他骨疾病)的女性发展子宫内膜癌的风险是不使用此类药物妇女患子宫内膜癌风险的一半左右。

此项研究发表于Cancer杂志上,研究表明这种类型的药物有一定抗癌作用。在美国,近50%的妇科癌症为子宫内膜癌,而且它是第四个最常见的恶性肿瘤,是癌症死亡的第八最常见原因。

双膦酸盐是已知的能防止骨损失的药物,临床前研究表明,该药物也具有抗肿瘤作用,包括抑制肿瘤细胞增殖和侵入正常组织的能力。

为了评估双膦酸盐是否会有助于预防子宫内膜癌,Sharon Hensley Alford博士带领一个团队将总共29254名妇女被纳入在分析,在因素,包括年龄,种族,激素疗法的使用历史,吸烟状况,身体质量指数调整后,相比未服用双膦酸盐的女性,使用双膦酸盐的女性中只有一半人有可能发展子宫内膜癌。

其他的研究表明,双膦酸盐可降低患某些癌症的风险,但我们是第一次表明,双膦酸盐也可能导致子宫内膜癌的风险降低。(生物谷Bioon.com)

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Protective effect of bisphosphonates on endometrial cancer incidence in the PLCO data

Sharon Hensley Alford, Ramandeep Rattan, Thomas Buekers, and Adnan Munkarah.

BACKGROUND
Preclinical studies have demonstrated antitumor effects of bisphosphonates. The objective of the current study was to determine the effect of exposure to bisphosphonate on the incidence of endometrial cancer.

METHODS
The authors used data from the National Cancer Institute's Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial, which collected data on all cancers. In year 5, all participants were asked to complete a self-administered supplemental questionnaire (SQX) that included questions regarding bone medication use. For women without a cancer diagnosis at the time of the SQX, the authors identified whether a woman reported current or former use of a nitrogenous bisphosphonate (NBP), defined as ever-use, and compared them with women never exposed to an NBP. Women with missing information were excluded as were women who reported undergoing a hysterectomy. Incidence rates and rate ratios were calculated with 95% confidence intervals (95% CIs). Cox proportional hazard ratios were also calculated and adjusted for covariates.

RESULTS
A total of 29,254 women were included in the current analysis; an additional 77 cases of endometrial cancer have been diagnosed since the SQX. The incidence rate for endometrial cancer among women exposed to NBPs was 8.7 per 10,000 person-years versus 17.7 per 10,000 person-years among never-exposed women (rate ratio, 0.49; 95% CI, 0.30-0.80). The effect was similar after adjusting for all the covariates in the Cox proportional hazards analysis, with a hazard ratio of 0.56 (95% CI, 0.34-0.93).

CONCLUSIONS
The results of the current study suggest that use of NBPs may have a protective effect on the incidence of endometrial cancer. However, additional studies are needed that include other potential confounders and a larger sample.

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