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Carcinogenesis:花生中的花生凝集素可加剧癌症扩散

来源:生物谷 2014-12-22 11:23

2014年12月22日讯 /生物谷BIOON/ --利物浦大学科学家发现花生中的一个组成成分可以刺激体内癌细胞的扩散和存活。

科学家们发现,花生蛋白质称为花生凝集素(PNA)结合于一个特殊的糖链(这主要存在于癌前细胞和癌细胞),并与血液循环中肿瘤细胞表面上表达的一个较大的蛋白相互作用。该研究显示这种相互作用会触发肿瘤表面较大蛋白变化,导致癌细胞表面上的粘附分子外露。

这就使得癌细胞更容易地粘附在血管,它也允许癌细胞以形成小团块“癌栓”,延长癌细胞在血液循环中的生存。利物浦科学家以前研究表明,花生凝集素(PNA)是耐蒸煮和消化,摄取生的或烤花生后,花生中高达50%的PNA进入机体,迅速以完整和活性形式进入血液。

Lugang Yu教授领导了这项研究,解释道:有生物学和流行病学证据提示饮食与癌症有因果关系,如酗酒和结肠直肠癌风险较高有相关性,但较少指导饮食对癌症发展的影响。

这项研究提供证据证明血液循环中PNA增强了肿瘤细胞扩散到身体其他部位的能力。这项研究发表在Carcinogenesis杂志上。(生物谷Bioon.com)

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Peanut agglutinin appearance in the blood circulation after peanut ingestion mimics the action of endogenous galectin-3 to promote metastasis by interaction with cancer-associated MUC1.

Qicheng Zhao,et al.

Peanut agglutinin (PNA), which accounts for ~0.15% of the weight of the common peanut, is a carbohydrate-binding protein that binds the oncofoetal Thomsen–Friedenreich (TF) disaccharide (galactoseβ1,3N-acetylgalactosamineα-) that is overexpressed by ~90% of human cancers. Previous studies have shown that PNA is highly resistant to cooking and digestion and rapidly enters the human blood circulation after peanut ingestion. This study investigates the hypothesis that PNA appearance in the circulation after peanut ingestion may mimic the actions of endogenous TF-binding human galectin-3 in metastasis promotion. It shows that PNA at concentrations similar to those found in blood circulation after peanut ingestion increases cancer cell heterotypic adhesion to the blood vascular endothelium and enhances the formation of tumour cell homotypic aggregates, two important steps in the metastasis cascade, and enhances metastasis in a mouse metastasis model. These effects of PNA are shown to result from its interaction with the cancer-associated TF disaccharide on the transmembrane mucin protein MUC1, causing MUC1 cell surface polarization that reveals underlying cell surface adhesion molecules. Thus, PNA appearance in the blood circulation after peanut ingestion mimics the actions of endogenous galectin-3 and promotes cancer cell metastatic spread by interaction with cancer-associated TF/MUC1. As metastasis accounts for the majority of cancer-associated fatality, regular consumption of peanuts by cancer patients would therefore be expected to have an adverse effect on cancer survival.

 

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