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帕金森氏症患者肠道菌群特殊

来源:生物谷 2014-12-16 10:33

2014年12月16日讯 /生物谷BIOON/ --根据赫尔辛基大学和赫尔辛基大学中心医院进行的一项研究发现,与健康对照者相比,帕金森氏症患者肠道有不同菌群。研究人员目前正在试图确定肠道微生物和帕金森氏症之间的联系。

我们最重要的发现是,帕金森病患者肠道中有比较少的普雷沃氏菌家族细菌,不同与对照组,帕金森病患者肠道几乎没有人有这个家族的大量细菌。这项研究发表在Movement Disorders杂志上。

研究人员尚未确定帕金森患者缺乏普雷沃氏菌科意味着什么,这些细菌是否可能保护他们的主人?还是缺乏普雷沃氏菌科只是患者肠功能紊乱病理的一部分? Sheperjans说:这是我们正试图回答的一个有趣问题。

另一个有趣的发现是,肠杆菌科中肠道菌的量与患者平衡和行走问题的严重程度相关联。患者有越多的肠杆菌科,就会有更严重的症状。

我们目前正在努力确定这些菌群差异是否是永久性的,是否肠道细菌与疾病的进展以及预后相关。此外,我们将分析是否细菌生态系统的这些变化是否在运动症状出现前就已经存在。(生物谷Bioon.com)

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Gut microbiota are related to Parkinson's disease and clinical phenotype.

Scheperjans F, et al.

In the course of Parkinson's disease (PD), the enteric nervous system (ENS) and parasympathetic nerves are amongst the structures earliest and most frequently affected by alpha-synuclein pathology. Accordingly, gastrointestinal dysfunction, in particular constipation, is an important non-motor symptom in PD and often precedes the onset of motor symptoms by years. Recent research has shown that intestinal microbiota interact with the autonomic and central nervous system via diverse pathways including the ENS and vagal nerve. The gut microbiome in PD has not been previously investigated. We compared the fecal microbiomes of 72 PD patients and 72 control subjects by pyrosequencing the V1-V3 regions of the bacterial 16S ribosomal RNA gene. Associations between clinical parameters and microbiota were analyzed using generalized linear models, taking into account potential confounders. On average, the abundance of Prevotellaceae in feces of PD patients was reduced by 77.6% as compared with controls. Relative abundance of Prevotellaceae of 6.5% or less had 86.1% sensitivity and 38.9% specificity for PD. A logistic regression classifier based on the abundance of four bacterial families and the severity of constipation identified PD patients with 66.7% sensitivity and 90.3% specificity. The relative abundance of Enterobacteriaceae was positively associated with the severity of postural instability and gait difficulty. These findings suggest that the intestinal microbiome is altered in PD and is related to motor phenotype. Further studies are warranted to elucidate the temporal and causal relationships between gut microbiota and PD and the suitability of the microbiome as a biomarker.

 

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