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J Neurol:外伤性脑损伤对长期记忆的影响

  1. 个体
  2. 外伤性脑损伤
  3. 影响
  4. 长期记忆

来源:生物谷 2014-12-03 11:36

近日,来自凯斯勒基金会的研究人员通过研究揭示了外伤性脑损伤(TBI)对个体长期记忆的影响,相关研究发表于国际杂志Journal of Neurology上。

2014年12月3日 讯 /生物谷BIOON/ --近日,来自凯斯勒基金会的研究人员通过研究揭示了外伤性脑损伤(TBI)对个体长期记忆的影响,相关研究发表于国际杂志Journal of Neurology上。

记忆损伤影响着54%至84%的TBI患者,如今人们很清楚TBI对个体长期记忆的影响,但是这背后隐藏的认知机制却不清楚,然而这种损害的可变性在和TBI相似的损伤个体中已经被揭示了,实际上是被认知储备的理论所解释的,比如较高的知识储备会对个体的长期记忆起到一种保护作用。

为了检测认知储备保护效应中的工作记忆在个体长期记忆中的角色,研究人员评估了50名中度及重度TBI患者的工作记忆,长期记忆及认知储备。研究者Sandry博士表示,我们的研究结果揭示,个体的工作记忆或许可以作为一种可能性的介质,来帮助调节认知储备和长期记忆间的关系。当然我们还需要进行更多的研究来确定在患者认知康复试验中工作记忆的价值。

最后研究人员表示,是否针对工作记忆的疗法策略可以导致TBI患者及其它记忆损伤患者的长期记忆损伤还需有待于进一步分析研究才可以证实。(生物谷Bioon.com)

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Working memory capacity links cognitive reserve with long-term memory in moderate to severe TBI: a translational approach.

Joshua Sandry, John DeLuca, Nancy Chiaravalloti

Traumatic brain injury (TBI) can have devastating negative consequences on an individuals’ ability to remember information; however, there is variability among memory impairment resulting from TBI. Some individuals exhibit long-term memory (LTM) impairment while others do not. This variability has been explained, at least in part, by the theory of cognitive reserve (CR). The theory suggests that individuals who have spent significant time engaged in intellectually enriching activities (higher CR) are better able to withstand LTM impairment despite neurological injury. The cognitive mechanisms that underlie this relationship are not well-specified. Recent evidence suggests that working memory (WM) capacity may be one mediating variable that can help explain how/why cognitive reserve (CR) protects against LTM impairment. The present research tested this hypothesis in a sample of fifty moderate to severe TBI patients. Specific neuropsychological tests were administered to estimate CR, LTM and WM. The results were congruent with a recent theoretical model that implicates WM capacity as a mediating variable in the relationship between CR and LTM (Sobel’s Z = 2.62, p = 0.009). These data corroborate recent findings in an alternate neurological population and suggest that WM is an underlying mechanism of CR. Additional research is necessary to establish whether (1) WM is an important individual difference variable to include in memory rehabilitation trials and (2) to determine whether rehabilitation and treatment strategies that specifically target WM may also lead to complimentary improvements on diagnostic tests of delayed LTM in TBI and other memory impaired populations.

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