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Clin Infect Dis:HIV感染个体或患年龄相关疾病的风险较高

  1. HIV
  2. 个体
  3. 年龄相关疾病
  4. 感染
  5. 癌症
  6. 风险

来源:生物谷 2014-11-13 10:06

近日,一项来自约翰霍普金斯大学的研究称,相比未感染HIV的成年个体来讲,相同年龄段感染HIV的成年个体或患心脏病发作、肾衰及癌症的风险较高,相关研究发表于国际杂志Clinical Infectious Diseases上,本文研究或为HIV感染者的健康护理提供新的研究线索和依据。

2014年11月13日 讯 /生物谷BIOON/ --近日,一项来自约翰霍普金斯大学的研究称,相比未感染HIV的成年个体来讲,相同年龄段感染HIV的成年个体或患心脏病发作、肾衰及癌症的风险较高,相关研究发表于国际杂志Clinical Infectious Diseases上,本文研究或为HIV感染者的健康护理提供新的研究线索和依据。

Keri N. Althoff教授表示,我们并没有找到确凿的证据证实,相比未感染HIV的成年人,癌症等疾病会在年轻的HIV感染者机体中发生;文章中利用2003年4月1日至2010年12月31期间对98687名HIV感染者和未感染者进行的队列研究数据,研究人员对比了每组个体被诊断为心脏病、肾衰及癌症的年龄,结果显示,HIV感染的个体被诊断为肾衰的年龄平均比未感染个体要年轻半岁,而诊断为心脏病及癌症的感染个体及未感染个体间在年龄差异上并无明显的统计学差异。

同时研究人员还比较了HIV感染者和未感染者患年龄相关疾病的风险,与前面研究类似,HIV感染个体患上述疾病(心脏病等)的风险明显增加,但这些疾病风险增加的程度不如之前的研究,这或许是由于研究中对某些因素进行了调节,比如肥胖、吸烟、糖尿病等。在AIDS流行的早些年人们认为HIV感染就是死路一条,然而近些年来由于抗逆转录病毒疗法的使用可以帮助感染者有效抑制HIV的复制,并且增加感染者的生存。

随着HIV感染者的寿命延长,科学家就出现了一种争论,即是否病毒感染会加速感染个体的老化过程,于是研究者就开展了这一研究,当前研究数据显示,心脏病、肾衰及癌症的发生在HIV感染者和未感染者之间是类似的,但这并不意味着HIV感染者就是健康的。许多HIV感染个体看起来比其实际年龄要老一些,而本文研究也分析探讨了三种年龄相关疾病和HIV感染的关联,后期研究者还需要进行更深入的研究来清楚解析年龄老化疾病和HIV感染之间的具体关联。(生物谷Bioon.com)

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Comparison of risk and age at diagnosis of myocardial infarction, end-stage renal disease, and non-AIDS-defining cancer in HIV-infected vs uninfected adults

Keri N. Althoff1, Kathleen A. McGinnis2, Christina M. Wyatt3, Matthew S. Freiberg2, Cynthia Gilbert4, Krisann K. Oursler5, David Rimland6, Maria C. Rodriguez-Barradas7, Robert Dubrow8, Lesley S. Park8, Melissa Skanderson8, Meredith S. Shiels9, Stephen J. Gange1, Kelly A. Gebo1, and Amy C. Justice8 for the Veterans Aging Cohort Study (VACS)

Background. Although it has been shown that HIV-infected adults are at greater risk for aging-associated events, it remains unclear as to whether these events happen at similar, or younger ages, in HIV-infected compared to uninfected adults. The objective of this study was to compare the median age at, and risk of, incident diagnosis of three age-associated diseases in HIV-infected and similar uninfected adults. Methods. The study was nested in the clinical, prospective Veterans Aging Cohort Study of HIV-infected and demographically-matched uninfected veterans, from April 1, 2003 to December 31, 2010. The outcomes were validated diagnoses of myocardial infarction (MI), end-stage renal disease (ESRD), and non-AIDS-defining cancers (NADC). Differences in mean age at, and risk of, diagnosis by HIV status were estimated using multivariate linear regression models and Cox proportional hazards models, respectively. Results. A total of 98,687 (31% HIV-infected and 69% uninfected) adults contributed >450,000 person-years and 689 MI, 1,135 ESRD, and 4,179 NADC incident diagnoses. Mean age at MI (adjusted mean difference: -0.11 (95% confidence interval [-0.59, 0.37] years) and NADC (adjusted mean difference: -0.10 [-0.30, 0.10] years), did not differ by HIV status. HIV-infected adults were diagnosed with ESRD at an average age of 5.5 months younger than uninfected adults (adjusted mean difference: -0.46 [-0.86, -0.07] years). HIV-infected adults had a greater risk of all three outcomes compared to uninfected adults after accounting for important confounders. Conclusions. HIV-infected adults had a higher risk of these age-associated events, but they occurred at similar ages than those without HIV.

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