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J Thora Oncol:科学家鉴别出肺部外围鳞状细胞癌的预后因子

  1. 肺部外围鳞状细胞癌
  2. 血清
  3. 预后因子

来源:生物谷 2014-10-28 14:40

近日,刊登在国际杂志the Journal of Thoracic Oncology上的一篇研究论文中,来自日本庆应大学医学院等处的研究人员对280名通过手术移除外围鳞状细胞癌的病人进行临床及病理学改变评估,用以鉴别患者的潜在预后因子。

2014年10月28日 讯 /生物谷BIOON/ --外围鳞状细胞癌是一种类型的非小细胞肺癌(NSCLC),患者较好的预后往往和血液中鳞状细胞癌抗原水平降低直接相关。肺癌是引发人类死亡常见癌症中的一种,而肺鳞状细胞癌(SCC)可以占非小细胞肺癌的20%至30%;依据发病位点,SCC又可被分为中央鳞状细胞癌(c-SCC)和外围鳞状细胞癌(p-SCC),当c-SCC主要流行时,p-SCC的发生率就会增加,而且其临床和生物学行为目前无人知晓。

近日,刊登在国际杂志the Journal of Thoracic Oncology上的一篇研究论文中,来自日本庆应大学医学院等处的研究人员对280名通过手术移除外围鳞状细胞癌的病人进行临床及病理学改变评估,用以鉴别患者的潜在预后因子。

文章中,研究者揭示,血清中鳞状细胞癌抗原术前水平较低,或肿瘤入侵胸膜缺失是任何阶段外围鳞状细胞癌患者独立的预后因素,而这些患者在病情不复发时其生存期往往更长,而且对于早期第1阶段的病人亚群来讲亦是如此。这项研究揭示,血清中肺鳞状细胞癌抗原水平较高的外围鳞状细胞癌患者相比血清中肺鳞状细胞癌抗原较低的个体更易于复发,而胸膜和血管的入侵是外围鳞状细胞癌恶化及转移的关键步骤。

最后,研究者指出,我们必须进行临床试验来评估,是否术后化疗会对那些疾病处于早期阶段、并不接受化疗的患者具有明显的益处。(生物谷Bioon.com)

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Prognostic Factors Based on Clinicopathological Data Among the Patients with Resected Peripheral Squamous Cell Carcinomas of the Lung.

Kinoshita, Tomonari MD; Ohtsuka, Takashi MD, PhD; Hato, Tai MD, PhD; Goto, Taichiro MD, PhD; Kamiyama, Ikuo MD; Tajima, Atsushi MD, PhD; Emoto, Katsura MD; Hayashi, Yuichiro MD; Kohno, Mitsutomo MD, PhD

Introduction: Although the incidence of peripheral squamous cell carcinomas (p-SqCCs) of the lung has increased over recent years, clinicopathological factors influencing prognosis of resected p-SqCCs remain unclear. Methods: We examined 280 patients who underwent complete resection of SqCCs and analyzed the clinicopathological features in relation to their overall survival (OS) and recurrence-free survival (RFS) according to the primary location. Results: Multivariate analysis of all stages of p-SqCCs patients revealed that high serum squamous cell carcinoma antigen (SCC) level (OS; p < 0.01, RFS; p < 0.01), vascular invasion (OS; p < 0.01, RFS; p < 0.01), pleural invasion (OS; p = 0.03, RFS; p = 0.01), nodal metastasis (OS; p = 0.02) and complication with lung disease (OS; p < 0.01) were independently unfavorable prognostic factors. Among stage I p-SqCCs patients, high serum SCC level (OS; p < 0.01, RFS; p < 0.01), vascular invasion (RFS; p < 0.01) and pleural invasion (RFS; p = 0.01) were also strongly correlated with poor prognosis independently. When we reevaluated the survival rate, T1 p-SqCCs with high serum SCC level or vascular invasion can be upgraded to T2a. Patients with stage IB had a significantly poorer prognosis than stage IA (5-year RFS; 61.4 % versus 76.6 %, p < 0.05). Conclusion: High serum SCC level, pleural and vascular invasions were independent poor prognostic factors for completely resected p-SqCCs. T1 p-SqCCs with high serum SCC level or vascular invasion should be upgraded to T2a, which accurately reflect survival status among patients with p-SqCCs.

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