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首页 » 组学 » Alzhe & Demen:单纯疱疹病毒或可增加个体患阿尔兹海默氏症的风险

Alzhe & Demen:单纯疱疹病毒或可增加个体患阿尔兹海默氏症的风险

来源:生物谷 2014-10-22 09:33

2014年10月22日 讯 /生物谷BIOON/ --近日,刊登在国际杂志Alzheimer's & Dementia上的两篇研究报道中,来自瑞典于默奥大学(Umea University)的研究人员通过研究发现,单纯疱疹病毒的感染或可增加个体患阿尔兹海默氏症的风险。

研究人员Hugo Lovheim表示,我们的研究结果清楚地解析了单纯疱疹病毒感染和阿尔兹海默氏症患病之间的关联;这就意味着我们或许可以开发治疗阿尔兹海默氏症的新型疗法。阿尔兹海默氏症是最常见的老年痴呆症疾病,近些年来对阿尔兹海默氏症的很多研究都揭示了1型单纯疱疹病毒的感染和个体患阿尔兹海默氏症之间的关系。

然而大部分人在其机体都会携带有单纯疱疹病毒,在机体感染初期病毒会异常活跃引发机体产生口腔溃疡;而假设单纯疱疹病毒和阿尔兹海默氏症之间的关联是基于老年人机体免疫系统功能的衰减,从而使得病毒容易在大脑中进行感染扩散,由于病毒的侵染就会影响个体大脑的功能进而导致阿尔兹海默氏症的发生。

在第一项研究中,研究者揭示了,疱疹病毒的再度活化可以加倍个体患阿尔兹海默氏症的风险,该研究对3432名个体平均进行了长达11.3年的跟踪研究;在第二项研究中,研究者对来自于默奥大学医学生物库中捐献的360份阿尔兹海默氏症患者的机体样本进行了检测,结果显示,如果个体携带有疱疹病毒那么其患阿尔兹海默氏症的风险会加倍。

最后研究者表示,如今我们利用抗病毒药物来治疗疱疹病毒的感染,我们希望通过后期的研究或许可以利用这种抗病毒的药物来抑制并且治疗个体的阿尔兹海默氏症。(生物谷Bioon.com)

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Herpes simplex infection and the risk of Alzheimer's disease—A nested case-control study

Hugo Lövheim, Jonathan Gilthorpe, Anders Johansson, Sture Eriksson, Göran Hallmans, Fredrik Elgh

Background Herpes simplex virus (HSV) is thought to play an etiological role in the development of Alzheimer's disease (AD). Methods Plasma samples from 360 AD cases (75.3% women, mean age 61.2 years) and 360 age- and sex-matched dementia-free controls, taken on average 9.6 years before AD diagnosis, were analyzed for anti-HSV antibodies (immunoglobulin G, IgG, and immunoglobulin M, IgM) by enzyme-linked immunosorbent assays. Results In the complete sample group, the presence of anti-HSV IgG and IgM antibodies did not increase the risk of AD significantly (odds ratio (OR) 1.636, P = .069 and OR 1.368, P = .299, respectively). In cases with 6.6 years or more between plasma sampling and AD diagnosis (n = 270), there was a significant association between presence of anti-HSV IgG antibodies and AD (OR 2.250, P = .019). Conclusion Among persons with a follow-up time of 6.6 years or more, HSV infection was significantly associated with AD.

 

Reactivated herpes simplex infection increases the risk of Alzheimer's disease

Hugo Lövheim, Jonathan Gilthorpe, Rolf Adolfsson, Lars-Göran Nilsson, Fredrik Elgh

Background Previous studies have suggested a link between herpes simplex virus (HSV) type 1 and the development of Alzheimer's disease (AD). Methods The present analysis included 3432 persons (53.9% women, mean age at inclusion 62.7 ± 14.4 years) with a mean follow-up time of 11.3 years. The number of incident AD cases was 245. Serum samples were analyzed for anti-HSV antibodies (immunoglobulin (Ig)G and IgM) by enzyme-linked immunosorbent assays. Results The presence of anti-HSV IgG antibodies was not associated with an increased risk for AD, controlled for age and sex (hazard ratio, HR, 0.993, P = .979). However, the presence of anti-HSV IgM at baseline was associated with an increased risk of developing AD (HR 1.959, P = .012). Conclusion Positivity for anti-HSV IgM, a sign of reactivated infection, was found to almost double the risk for AD, whereas the presence of anti-HSV IgG antibodies did not affect the risk.

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