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Cancer:科学家揭示引发胰腺癌的关键因素

来源:生物谷 2014-10-15 11:31

2014年10月15日 讯 /生物谷BIOON/ --发表在国际杂志Cancer上的一篇研究论文中,来自格拉斯格大学的研究人员通过研究揭示了引发胰腺癌的新型因子,为鉴别胰腺癌风险机体及开发新型胰腺癌疗法提供了一定的帮助和依据。

胰腺癌是一种很隐蔽的恶性癌症,其往往是在疾病的晚期阶段才被检测出来,而且患者的5年生存比率低于5%;尽早地鉴别出患病及风险个体对于进行患者的早期防治非常关键,而有些病例也是在家庭成员之间遗传的,但是促使疾病遗传的基因却尚不清楚。

为了更好地理解遗传性和非遗传性胰腺癌的临床特性,研究者Andrew Biankin博士及其同事对766名胰腺癌患者进行研究,如果这些患者都有受胰腺癌影响的直系亲属,那么其就被认为具有一定的遗传倾向,否则个体的癌症就被认为是散发病例。

在被研究的患者中,将近有9%的胰腺癌个体其父母一方或姊妹都曾被诊断为胰腺癌,当研究人员检测所有患者癌症患处附近的胰腺组织时他们其直系亲属机体中也存在更多的促癌性组织,研究者表示,这些个体患其它癌症的风险也较高,比如黑色素瘤及子宫内膜癌等。更为重要的是,在检测的人群中年龄较小的个体更容易去主动吸烟。

最后研究者Biankin表示,本文研究发现,个体从父母遗传下来的易感基因或许在其一生中在患胰腺癌的风险上扮演着重要角色,而且在我们评估个体患胰腺癌的风险时,评估其家庭的胰腺癌史及其它恶性疾病的发生也非常有必要,另外研究者的数据也强调了戒烟对疾病控制的重要性。(生物谷Bioon.com)

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Clinical and pathologic features of familial pancreatic cancer

Jeremy L. Humphris MBBS1, Amber L. Johns BMedSc1, Skye H. Simpson MSc1, Mark J. Cowley PhD1, Marina Pajic PhD1,8, David K. Chang MBBS, PhD1,3, Adnan M. Nagrial MBBS1, Venessa T. Chin MBBS1, Lorraine A. Chantrill MBBS1, Mark Pinese BSc1, R. Scott Mead MBBS, PhD1, Anthony J. Gill MBBS4,5, Jaswinder S. Samra MBBS5,6, James G. Kench MBBS1,7, Elizabeth A. Musgrove PhD3, Katherine M. Tucker MBBS2, Allan D. Spigelman MBBS1,8, Nic Waddell PhD9, Sean M. Grimmond PhD3,9, Andrew V. Biankin MBBS, PhD1,3,* andthe Australian Pancreatic Cancer Genome Initiative

BACKGROUND Inherited predisposition to pancreatic cancer contributes significantly to its incidence and presents an opportunity for the development of early detection strategies. The genetic basis of predisposition remains unexplained in a high proportion of patients with familial PC (FPC). METHODS Clinicopathologic features were assessed in a cohort of 766 patients who had been diagnosed with pancreatic ductal adenocarcinoma (PC). Patients were classified with FPC if they had ≥1 affected first-degree relatives; otherwise, they were classified with sporadic PC (SPC). RESULTS The prevalence of FPC in this cohort was 8.9%. In FPC families with an affected parent-child pair, 71% in the subsequent generation were 12.3 years younger at diagnosis. Patients with FPC had more first-degree relatives who had an extrapancreatic malignancy (EPM) (42.6% vs 21.2; P<.0001), particularly melanoma and endometrial cancer, but not a personal history of EPM. Patients with SPC were more likely to be active smokers, have higher cumulative tobacco exposure, and have fewer multifocal precursor lesions, but these were not associated with differences in survival. Long-standing diabetes mellitus (>2 years) was associated with poor survival in both groups. CONCLUSIONS FPC represents 9% of PC, and the risk of malignancy in kindred does not appear to be confined to the pancreas. Patients with FPC have more precursor lesions and include fewer active smokers, but other clinicopathologic factors and outcome are similar to those in patients with SPC. Furthermore, some FPC kindreds may exhibit anticipation. A better understanding of the clinical features of PC will facilitate efforts to uncover novel susceptibility genes and the development of early detection strategies. Cancer 2014. © 2014 American Cancer Society.

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