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Mol Nutr Food Res:石榴中发现能阻止阿尔茨海默氏症发展的化合物

来源:生物谷 2014-08-24 11:20

2014年8月25日讯 /生物谷BIOON/--在石榴中发现的一种天然化合物,可以减缓阿尔茨海默氏病的一些症状。此外,天然化合物也可以改善一些疼痛炎症如类风湿关节炎,根据由哈德斯菲尔德大学科学家Olumayokun Olajide博士等人开展的一项为期两年的项目,Olumayokun Olajide博士专门从事天然产物的抗发炎特性研究。

Olajide博士和他的同事研究证明安石榴甙(是一种多酚)能抑制小神经胶质细胞炎症。这种炎症导致越来越多的脑细胞破坏,后者的破坏会使得阿尔茨海默氏症患者的状况逐渐恶化。目前还没有治愈阿尔茨海默氏症的方法,但在石榴中发现的安石榴甙可以防止或减缓其发展。

Olajide博士研究小组用分离自大鼠的脑细胞以检验其结果。研究成果发表在杂志Molecular Nutrition & Food Research上。他们将继续探究石榴所需要的量,以便使其更有效。

我们知道,经常摄入并经常食用石榴有许多健康益处,包括预防神经炎症相关的老年痴呆症。但Olajide医生指出,大多数的抗氧化剂的化合物被发现在石榴的外皮中,而不是在水果果肉中。(生物谷Bioon.com)

Punicalagin inhibits neuroinflammation in LPS-activated rat primary microglia

A. Olumayokun A. Olajide, Asit Kumar, Ravikanth Velagapudi, Uchechukwu P. Okorji and Bernd L.

The ability of punicalagin to reduce the production of TNF-α, IL-6 and prostaglandin E2 was measured in culture medium using enzyme immunoassay. TNF-α and IL-6 gene expression in mouse hippocampal slices was measured with PCR. cyclooxygenase-2 and microsomal prostaglandin E synthase 1 protein and mRNA were evaluated with Western blotting and PCR, respectively. Further experiments to investigate effects of punicalagin on protein expressions of inflammatory targets were also determined with Western blotting. Pretreatment of rat primary microglia with punicalagin (5–40 μM) prior to LPS (10 ng/mL) stimulation produced a significant (p < 0.05) inhibition of TNF-α, IL-6 and prostaglandin E2 production. Punicalagin completely abolished TNF-α and IL-6 gene expression in LPS-stimulated hippocampal slices. Protein and mRNA expressions of cyclooxygenase-2 and microsomal prostaglandin E synthase 1 were also reduced by punicalagin pretreatment. Results show that punicalagin interferes with NF-κB signalling through attenuation of NF-κB-driven luciferase expression, as well as inhibition of IκB phosphorylation and nuclear translocation of p65 subunit in the microglia.

 

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