打开APP

体重超标?当心癌症找上门

  1. 体重
  2. 健康
  3. 癌症
  4. 超重

来源:生物谷 2014-08-16 16:24

近日,一项研究揭示:超重会导致患10种常见癌症的风险增加。 根据目前为止规模最大的,发表在The Lancet杂志上发表的一份研究声明:如果目前肥胖趋势继续发展下去,有可能每年,在英国将有超过3500多名的癌症患者。

2014年8月16日讯 /生物谷BIOON/--近日,一项研究揭示:超重会导致患10种常见癌症的风险增加。 研究显示,每年在英国出现的这10种癌症病例中,有1.2万个病例与超重有因果关系。

根据目前为止规模最大的,发表在The Lancet杂志上发表的一份研究声明:如果目前肥胖趋势继续发展下去,在英国每年有可能将有超过3500多名的癌症患者。按体重与身高的平方的比率计算,身体质量指数(BMI)在25到29.9之间被认为是超重,而30视为肥胖。

BMI每增加5 kg/m2,显然与子宫癌的风险较高(增长62%),胆囊癌(风险增加31%),肾脏癌(风险增加25%),子宫颈癌(风险增加10%),甲状腺癌(风险增加9%)和白血病(风险增加9%)存在相关性。

更高的BMI也有肝脏癌症(增加19%),结肠癌(增加10%),卵巢癌(增加9%)和乳腺癌(增加5%)的总体风险增加有关,但这四种类型的癌症也受其他因素影响。

研究发现:即使处于正常范围内的体重与身高比例,人们有更高的BMI,患癌风险也较大。研究人员发现:相反,具有较高BMI的人似乎患前列腺癌和绝经前患乳腺癌的风险较低。

研究人员用全国范围内数据网络上的病人病历,并确定了16岁以上的,524万人在他们第一次注册的时候无癌。对他们的健康状况进行随访,平均为期7.5年,在此期间,近167,000人患上某种形式的癌症。

主要研究人员Krishnan Bhaskaran说:BMI对不同癌症风险有不同影响。举个例子,身体质量指数大幅上升,患子宫癌症的风险较高,而对于其他癌症类型,我们看到的更多是风险中度增加,或身体质量指数大幅上升对患癌风险根本没有影响。

亚特兰大美国癌症协会Peter Campbell强调:对于降低患某些癌症类型风险,有必要遏制超重和肥胖。体重超重也使人们患心脏疾病和中风的风险较高,最近的一项全球性的研究分析发现,三分之一的成人,四分之一的儿童是超重的。(生物谷Bioon.com)

 

Body-mass index and risk of 22 specific cancers: a population-based cohort study of 5·24 million UK adults

r Krishnan Bhaskaran PhD,et al.

Background
High body-mass index (BMI) predisposes to several site-specific cancers, but a large-scale systematic and detailed characterisation of patterns of risk across all common cancers adjusted for potential confounders has not previously been undertaken. We aimed to investigate the links between BMI and the most common site-specific cancers.
Methods
With primary care data from individuals in the Clinical Practice Research Datalink with BMI data, we fitted Cox models to investigate associations between BMI and 22 of the most common cancers, adjusting for potential confounders. We fitted linear then non-linear (spline) models; investigated effect modification by sex, menopausal status, smoking, and age; and calculated population effects.
Findings
5·24 million individuals were included; 166 955 developed cancers of interest. BMI was associated with 17 of 22 cancers, but effects varied substantially by site. Each 5 kg/m2 increase in BMI was roughly linearly associated with cancers of the uterus (hazard ratio [HR] 1·62, 99% CI 1·56—1·69; p<0·0001), gallbladder (1·31, 1·12—1·52; p<0·0001), kidney (1·25, 1·17—1·33; p<0·0001), cervix (1·10, 1·03—1·17; p=0·00035), thyroid (1·09, 1·00—1·19; p=0·0088), and leukaemia (1·09, 1·05—1·13; p≤0·0001). BMI was positively associated with liver (1·19, 1·12—1·27), colon (1·10, 1·07—1·13), ovarian (1·09, 1.04—1.14), and postmenopausal breast cancers (1·05, 1·03—1·07) overall (all p<0·0001), but these effects varied by underlying BMI or individual-level characteristics. We estimated inverse associations with prostate and premenopausal breast cancer risk, both overall (prostate 0·98, 0·95—1·00; premenopausal breast cancer 0·89, 0·86—0·92) and in never-smokers (prostate 0·96, 0·93—0·99; premenopausal breast cancer 0·89, 0·85—0·94). By contrast, for lung and oral cavity cancer, we observed no association in never smokers (lung 0·99, 0·93—1·05; oral cavity 1·07, 0·91—1·26): inverse associations overall were driven by current smokers and ex-smokers, probably because of residual confounding by smoking amount. Assuming causality, 41% of uterine and 10% or more of gallbladder, kidney, liver, and colon cancers could be attributable to excess weight. We estimated that a 1 kg/m2 population-wide increase in BMI would result in 3790 additional annual UK patients developing one of the ten cancers positively associated with BMI.

版权声明 本网站所有注明“来源:生物谷”或“来源:bioon”的文字、图片和音视频资料,版权均属于生物谷网站所有。非经授权,任何媒体、网站或个人不得转载,否则将追究法律责任。取得书面授权转载时,须注明“来源:生物谷”。其它来源的文章系转载文章,本网所有转载文章系出于传递更多信息之目的,转载内容不代表本站立场。不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。

87%用户都在用生物谷APP 随时阅读、评论、分享交流 请扫描二维码下载->