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Psychosom Med:工作压力是2型糖尿病危险因素

  1. 压力
  2. 工作
  3. 糖尿病

来源:生物谷 2014-08-11 14:56

职场压力可以对人体健康产生多种不良影响,比如增加心血管疾病风险。

2014年8月11日讯 /生物谷BIOON/--职场压力可以对人体健康产生多种不良影响,比如增加心血管疾病风险。然而,迄今为止,还没有有说服力的证据,证实工作压力和2型糖尿病之间有很强的相关性。

近日,由Cornelia Huth医生和Karl-Heinz Ladwig教授为首的科学家小组已经发现,工作压力大的人,患2型糖尿病的风险比那些工作压力小的人高出约45%。

亥姆霍兹慕尼黑中心(HMGU)Institute of Epidemiology II (EPI II)科学家审查了前瞻性收集数据(涉及5300名,29和66岁之间个体),这些人参加了人群为基础的MONICA/ KORA队列研究。

在研究开始时,没有参与者有糖尿病,而在观察后期,300人被诊断患有2型糖尿病。工作有关压力导致的糖尿病风险上升,独立于经典的危险因素,如肥胖,年龄或性别。

鉴于压力对健康有巨大影响,因此需要积极开发预防措施,防止常见的疾病如糖尿病。(生物谷Bioon.com)

doi:
PMC:
PMID:

Job Strain as a Risk Factor for the Onset of Type 2 Diabetes Mellitus: Findings From the MONICA/KORA Augsburg Cohort Study

Huth, C. et al.

OBJECTIVE:
To examine whether job strain is associated with an increased risk of subsequent Type 2 diabetes mellitus (T2DM) development in a population-based study of men and women.
METHODS:
Data were derived from the prospective MONICA/KORA Augsburg study. We investigated 5337 working participants aged 29 to 66 years without diabetes at one of the three baseline surveys. Job strain was measured by the Karasek job content questionnaire. High job strain was defined by the quadrant approach, where high job demands combined with low job control were classified as high job strain. Continuous job strain (quotient of job demands divided by job control) was additionally analyzed as sensitivity analysis. Hazard ratios (HRs) were estimated using multivariable Cox proportional hazards models with adjustment for age, sex, survey, socioeconomic and life-style variables, parental history of diabetes, and body mass index.
RESULTS:
During a median follow-up of 12.7 years, 291 incident cases of T2DM were observed. The participants with high job strain at baseline had a 45% higher fully adjusted risk to develop T2DM than did those with low job strain (HR = 1.45 [95% confidence interval = 1.00-2.10], p = .048). On the continuous scale, more severe job strain in the magnitude of 1 standard deviation corresponded to a 12% increased fully adjusted T2DM risk (HR = 1.12 [95% confidence interval = 1.00-1.25], p = .045).
CONCLUSIONS:
Men and women who experience high job strain are at higher risk for developing T2DM independently of traditional risk factors. Preventive strategies to combat the globally increasing T2DM epidemic should take into consideration the adverse effects of high strain in the work environment.

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