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J Immunol:自然分娩或更易增强新生儿免疫系统发育

来源:生物谷 2014-07-14 09:21

2014年7月14日 讯 /生物谷BIOON/ --许多研究都表明,相比自然出生的婴儿,剖腹产出生的婴儿机体往往具有不同的肠道菌群,但是发生这一现象的原因及其对机体免疫系统的影响尚不清楚;近日,来自哥本哈根大学的研究人员通过对新生小鼠进行研究,旨在揭示出生方式对小鼠机体免疫系统发育的影响,相关研究成果刊登于国际杂志The Journal of Immunology上。

研究者发现,通过剖腹产出生的小鼠幼崽机体中增强免疫系统的细胞数量往往较少,而通过自然分娩方式出生的幼崽相比剖腹产来讲可以暴露于更多细菌中,研究者提出了一种卫生假说,即自然分娩方式出生的幼崽,其机体免疫系统可以学会区分无害分子和外来分子。

剖腹产出生的幼崽机体特殊细胞的含量较少,而这种细胞在抑制反应性免疫细胞对自身分子、饮食及无害肠道菌群上产生反应上扮演着重要作用。自身免疫疾病比如I型糖尿病、克罗恩病及过敏症,其都是由于免疫系统过度反应而引发的疾病。

随后研究人员在剖腹产出生的幼崽机体中寻找I型糖尿病发生的迹象,结果并没有找到,下一步研究人员将会深入研究研究来鉴别是否剖腹产出生的幼崽更易于患其它类型的自身免疫疾病,并且进行进一步的临床研究;对小鼠模型进行研究为揭示人类很多疾病发生的分子机制提供了一定的线索,因此从长远角度来讲,研究者需要开发出加强新生儿免疫系统发育的方法以防止其患自身免疫疾病。(生物谷Bioon.com)

Mode of Delivery Shapes Gut Colonization Pattern and Modulates Regulatory Immunity in Mice

Camilla H. F. Hansen*,1, Line S. F. Andersen*,1, Łukasz Krych†, Stine B. Metzdorff*, Jane P. Hasselby‡, Søren Skov*, Dennis S. Nielsen†, Karsten Buschard§, Lars H. Hansen¶‖ and Axel K. Hansen*

Delivery mode has been associated with long-term changes in gut microbiota composition and more recently also with changes in the immune system. This has further been suggested to link Cesarean section (C-section) with an increased risk for development of immune-mediated diseases such as type 1 diabetes. In this study, we demonstrate that both C-section and cross-fostering with a genetically distinct strain influence the gut microbiota composition and immune key markers in mice. Gut microbiota profiling by denaturing gradient gel electrophoresis and 454/FLX-based 16S rRNA gene amplicon sequencing revealed that mice born by C-section had a distinct bacterial profile at weaning characterized by higher abundance of Bacteroides and Lachnospiraceae, and less Rikenellaceae and Ruminococcus. No clustering according to delivery method as determined by principal component analysis of denaturing gradient gel electrophoresis profiles was evident in adult mice. However, the adult C-section–born mice had lower proportions of Foxp3+ regulatory T cells, tolerogenic CD103+ dendritic cells, and less Il10 gene expression in mesenteric lymph nodes and spleens. This demonstrates long-term systemic effect on the regulatory immune system that was also evident in NOD mice, a model of type 1 diabetes, born by C-section. However, no effect of delivery mode was seen on diabetes incidence or insulitis development. In conclusion, the first exposure to microorganisms seems to be crucial for the early life gut microbiota and priming of regulatory immune system in mice, and mode of delivery strongly influences this.

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