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J Immunol:自然分娩可增强胎儿免疫系统

  1. 免疫系统
  2. 胎儿
  3. 自然分娩

来源:生物谷 2014-07-11 09:35

大量的研究表明,剖腹产婴儿与自然分娩婴儿有不同的肠道菌群。但仍不甚明了,为什么是这样的,以及这种差异性对免疫系统意味着什么。近日,哥本哈根大学研究人员决定利用新生小鼠幼崽评定两种出生方式对免疫系统发育

2014年7月11日讯 /生物谷BIOON/--大量的研究表明,剖腹产婴儿与自然分娩婴儿有不同的肠道菌群。但仍不甚明了,为什么是这样的,以及这种差异性对免疫系统意味着什么。近日,哥本哈根大学研究人员决定利用新生小鼠幼崽评定两种出生方式对免疫系统发育的影响。

研究表明,通过剖腹产的小鼠幼仔只拥有较低数量的用于增强免疫系统的细胞类型。该研究结果最近发表在Journal of Immunology杂志上。

与那些剖腹产胎儿相比,自然分娩的胎儿更多暴露于来自母亲的细菌。有一个研究假设,即新生宝宝的免疫系统以这种方式来获知区别对自己无害的分子和外源入侵分子的能力。

在该实验中,剖腹产幼仔只拥有较低数量的一种细胞类型,此细胞类型在防止反应性免疫细胞对来自机体本身,饮食的分子和无害肠道细菌的响应中起重要作用。

自身免疫性疾病如1型糖尿病,Chrohn氏病和过敏的特征在于免疫系统的过度反应。接着,研究人员寻找剖腹产幼仔发展1型糖尿病的迹象,但没有发现相关迹象。因此,下一步就是要研究幼仔是否易患其他自身免疫性疾病,然后,在临床试验中测试这些结果。

从长远来看,利用此项研究也许能够开发出加强易患自身免疫性疾病新生儿免疫系统的新方法。(生物谷Bioon.com)

Mode of Delivery Shapes Gut Colonization Pattern and Modulates Regulatory Immunity in Mice

Camilla H. F. Hansen,et al

Delivery mode has been associated with long-term changes in gut microbiota composition and more recently also with changes in the immune system. This has further been suggested to link Cesarean section (C-section) with an increased risk for development of immune-mediated diseases such as type 1 diabetes. In this study, we demonstrate that both C-section and cross-fostering with a genetically distinct strain influence the gut microbiota composition and immune key markers in mice. Gut microbiota profiling by denaturing gradient gel electrophoresis and 454/FLX-based 16S rRNA gene amplicon sequencing revealed that mice born by C-section had a distinct bacterial profile at weaning characterized by higher abundance of Bacteroides and Lachnospiraceae, and less Rikenellaceae and Ruminococcus. No clustering according to delivery method as determined by principal component analysis of denaturing gradient gel electrophoresis profiles was evident in adult mice. However, the adult C-section–born mice had lower proportions of Foxp3+ regulatory T cells, tolerogenic CD103+ dendritic cells, and less Il10 gene expression in mesenteric lymph nodes and spleens. This demonstrates long-term systemic effect on the regulatory immune system that was also evident in NOD mice, a model of type 1 diabetes, born by C-section. However, no effect of delivery mode was seen on diabetes incidence or insulitis development. In conclusion, the first exposure to microorganisms seems to be crucial for the early life gut microbiota and priming of regulatory immune system in mice, and mode of delivery strongly influences this.

 

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