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J Neuroimmune Pharm:肉桂或可制止帕金森氏病进展

来源:生物谷 2014-07-11 09:25

2014年7月11日讯 /生物谷BIOON/--近日,Rush大学医学中心神经科学家发现使用肉桂,一种常见的食品香料和调味料,可以逆转帕金森病(PD)小鼠大脑中发生的生物力学,细胞和解剖学变化。该研究结果最近发表在6月20日发行的Journal of Neuroimmune Pharmacology杂志上。

几个世纪以来,在世界各地,肉桂已被广泛用作香料,研究员Kalipada Pahan教授说:因此,这可能是阻止帕金森氏症患者疾病进展最安全的方法之一。

肉桂在肝脏中被代谢成苯甲酸钠,苯甲酸钠是FDA批准用于治疗与高氨血症相关的肝代谢缺陷的药物,Pahan说:它也被广泛用作食品防腐剂,由于其具有杀微生物效果。

在美国销售的有中国肉桂(桂皮樟)和锡兰肉桂(樟属八角),肉桂的两种主要类型。通过质谱分析,虽然这两种类型的肉桂都被代谢成苯甲酸钠,但我们已经看到锡兰肉桂比桂皮樟更纯粹(更安全),因为后者含有香豆素(一个肝毒性分子)。

了解这种疾病的工作对于开发保护大脑和停止PD进展有效药物是非常重要的,已知一些重要的蛋白质如帕金和DJ-1在帕金森病患者大脑中是减少的。研究发现,经口服后,肉桂粉被代谢成苯甲酸钠,然后进入大脑,停止帕金和DJ-1的丢失,保护神经元,恢复神经递质的正常水平,并改善PD小鼠运动功能。

现在,我们需要将这一发现转化为临床实验,在PD患者中试验肉桂粉。如果这些结果在PD患者中得到复制,这将是治疗神经退行性疾病的显著进步。(生物谷Bioon.com)

Cinnamon Treatment Upregulates Neuroprotective Proteins Parkin and DJ-1 and Protects Dopaminergic Neurons in a Mouse Model of Parkinson’s Disease

Saurabh Khasnavis, Kalipada Pahan

Upregulation and/or maintenance of Parkinson’s disease (PD)-related beneficial proteins such as Parkin and DJ-1 in astrocytes during neurodegenerative insults may have therapeutic efficacy in PD. Cinnamon is a commonly used natural spice and flavoring material throughout the world. Here we have explored a novel use of cinnamon in upregulating Parkin and DJ-1 and protecting dopaminergic neurons in MPTP mouse model of PD. Recently we have delineated that oral feeding of cinnamon (Cinnamonum verum) powder produces sodium benzoate (NaB) in blood and brain of mice. Proinflammatory cytokine IL-1β decreased the level of Parkin/DJ-1 in mouse astrocytes. However, cinnamon metabolite NaB abrogated IL-1β-induced loss of these proteins. Inability of TNF-α to produce nitric oxide (NO) and decrease the level of Parkin/DJ-1 in wild type (WT) astrocytes, failure of IL-1β to reduce Parkin/DJ-1 in astrocytes isolated from iNOS (-/-) mice, and decrease in Parkin/DJ-1 in WT astrocytes by NO donor DETA-NONOate suggest that NO is a negative regulator of Parkin/DJ-1. Furthermore, suppression of IL-1β-induced expression of iNOS in astrocytes by NaB and reversal of NaB-mediated protection of Parkin/DJ-1 by DETA-NONOate in astrocytes indicate that NaB protects Parkin/DJ-1 in activated astrocytes via suppressing iNOS. Similarly MPTP intoxication also increased the level of iNOS and decreased the level of Parkin/DJ-1 in vivo in the nigra. However, oral treatment of MPTP-intoxicated mice with cinnamon powder and NaB reduced the expression of iNOS and protected Parkin/DJ-1 in the nigra. These findings paralleled dopaminergic neuronal protection, normalized striatal neurotransmitters, and improved motor functions by cinnamon in MPTP-intoxicated mice. These results suggest that cinnamon may be beneficial for PD patients.

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