打开APP

Diabetes Care:研究发现代谢综合征与较小脑组织体积相关

  1. 代谢综合征
  2. 小脑
  3. 脑体积

来源:生物谷 2014-07-11 13:39

根据发表在Diabetes Care杂志上的一项新研究报告指出:对于患有明显动脉疾病(代谢综合征(MetS)的某一特定情况)患者而言,其代谢综合征与较小的脑组织体积有关联,即使没有糖尿病的情况下此相关性仍存在。

2014年7月11日讯 /生物谷BIOON/--根据发表在Diabetes Care杂志上的一项新研究报告指出:对于患有明显动脉疾病(代谢综合征(MetS)的某一特定情况)患者而言,其代谢综合征与较小的脑组织体积有关联,即使没有糖尿病的情况下此相关性仍存在。

荷兰University Medical Center Utrecht的Audrey M. Tiehuis医学博士和他的同事研究1,232例明显动脉疾病患者(平均年龄58.6岁,37%有代谢症候群),这些患者经过脑磁磁共振成像,发现代谢综合征与脑变化之间的相关性。脑组织、脑室尺寸及大脑白质高信号量与颅内体积有相关性。

研究人员发现,某些代谢症候群与较小的脑组织体积相关,即使在没有糖尿病的患者中也存在。研究发现代谢综合征和白质高信号或脑梗死发生率增加之间没有关联。而与较小脑体积相关的代谢综合征特定情况包括糖代谢异常,腹型肥胖,和甘油三酯升高。

当糖尿病患者被排除在外,肥胖和高甘油三酯血症与较小的脑体积相关性仍然存在。高血压和白质高信号以及梗死发生率增加之间有关联。

筛查代谢综合征及其各个情况特别是高血糖,高甘油三酯血症,肥胖,可能会有助阻止代谢综合征患者认知老化的进展。(生物谷Bioon.com)

Metabolic Syndrome, Prediabetes, and Brain Abnormalities on MRI in Patients With Manifest Arterial Disease: The SMART-MR Study

Audrey M. Tiehuis,et al.

OBJECTIVE Metabolic syndrome (MetS) is a cluster of cardiovascular risk factors leading to atherosclerosis and diabetes. Diabetes is associated with both structural and functional abnormalities of the brain. MetS, even before diabetes is diagnosed, may also predispose to cerebral changes, probably through shared mechanisms. We examined the association of MetS with cerebral changes in patients with manifest arterial disease.

RESEARCH DESIGN AND METHODS Cross-sectional data on MetS and brain MRI were available in 1,232 participants with manifest arterial disease (age 58.6 ± 10.1 years; 37% MetS). Volumes of brain tissue, ventricles, and white matter hyperintensities (WMH) were obtained by automated segmentation and expressed relative to intracranial volume. Infarcts were distinguished into lacunar and nonlacunar infarcts.

RESULTS The presence of MetS (n = 451) was associated with smaller brain tissue volume (B 0.72% [95% CI 0.97, 0.47]), even in the subgroup of patients without diabetes (B 0.42% [95% CI 0.71, 0.13]). MetS was not associated with an increased occurrence of WMH or cerebral infarcts. Impaired glucose metabolism, abdominal obesity, and elevated triglycerides were individual components associated with smaller brain volume. Obesity and hypertriglyceridemia remained associated with smaller brain volume when patients with diabetes were excluded. Hypertension was associated with an increased occurrence of WMH and infarcts.

CONCLUSION In patients with manifest arterial disease, presence of MetS is associated with smaller brain volume, even in patients without diabetes. Screening for MetS and treatment of its individual components, in particular, hyperglycemia, hypertriglyceridemia, and obesity, may prevent progression of cognitive aging in patients with MetS, even in a prediabetic stage.

版权声明 本网站所有注明“来源:生物谷”或“来源:bioon”的文字、图片和音视频资料,版权均属于生物谷网站所有。非经授权,任何媒体、网站或个人不得转载,否则将追究法律责任。取得书面授权转载时,须注明“来源:生物谷”。其它来源的文章系转载文章,本网所有转载文章系出于传递更多信息之目的,转载内容不代表本站立场。不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。

87%用户都在用生物谷APP 随时阅读、评论、分享交流 请扫描二维码下载->