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首页 » 临床研究 » PNAS:缺乏睡眠的后果

PNAS:缺乏睡眠的后果

来源:生物谷 2014-07-10 09:05

2014年7月10日 讯 /生物谷BIOON/ --近日,刊登在国际杂志PNAS上一项研究表明,缺乏睡眠会影响人体的新陈代谢。这项研究对于在合适的时间去检查疾病比如癌症,心脏病还有对药物的有效管理是非常有用的。

研究者调查在睡眠缺乏,生物钟紊乱,新陈代谢与发现一天时间中一个清晰的代谢变化之间有一定的关系。

健康的成年男性志愿者被放置到一个环境中,在这个环境中,光线、睡眠、饮食和姿势都被有效控制。研究者每两小时收集一次血样为了观察一天之中代谢标记物如何改变。在开始的24小时当中,参与者经历了正常的睡眠与苏醒的循环。紧随24小时不休息的状态之后调查睡眠缺乏对代谢节律的影响。结果显示由于睡眠缺乏使得代谢过程显著增加。27种代谢物包括5-羟色胺,相比较于睡眠期,它在睡眠不足期会更高水平的出现。

文章的第一作者表示,如果我们要对一种疾病进行诊断测试,考虑到血样标本花费时间是非常有必要的,它对代谢地影响非常重要。这也对药品的管理是非常关键的,并且确定何时药品是最有效的。这被认为是案审理的方式,因为许多人如轮班工作者有不同的睡眠/唤醒周期和时间,这需要适应他们的生物钟。

研究者Florence Raynaud表明,研究精确测量大量的代谢物变化的时间和不同的睡眠模式。研究结果非常重要的解释了血液检测的结果,并且理解为什么有些人对药物的反应不同。他们在代谢过程和癌症等疾病之间也为未来研究设置参考点。(生物谷Bioon.com)

Effect of sleep deprivation on the human metabolome.

Sarah K. Daviesa, Joo Ern Angb, Victoria L. Revella, Ben Holmesa, Anuska Manna, Francesca P. Robertsona, Nanyi Cuia, Benita Middletona, Katrin Ackermannc,1, Manfred Kayserc, Alfred E. Thumsera, Florence I. Raynaudb,2, and Debra J. Skenea,2,3

Sleep restriction and circadian clock disruption are associated with metabolic disorders such as obesity, insulin resistance, and diabetes. The metabolic pathways involved in human sleep, however, have yet to be investigated with the use of a metabolomics approach. Here we have used untargeted and targeted liquid chromatography (LC)/MS metabolomics to examine the effect of acute sleep deprivation on plasma metabolite rhythms. Twelve healthy young male subjects remained in controlled laboratory conditions with respect to environmental light, sleep, meals, and posture during a 24-h wake/sleep cycle, followed by 24 h of wakefulness. Two-hourly plasma samples collected over the 48 h period were analyzed by LC/MS. Principal component analysis revealed a clear time of day variation with a significant cosine fit during the wake/sleep cycle and during 24 h of wakefulness in untargeted and targeted analysis. Of 171 metabolites quantified, daily rhythms were observed in the majority (n = 109), with 78 of these maintaining their rhythmicity during 24 h of wakefulness, most with reduced amplitude (n = 66). During sleep deprivation, 27 metabolites (tryptophan, serotonin, taurine, 8 acylcarnitines, 13 glycerophospholipids, and 3 sphingolipids) exhibited significantly increased levels compared with during sleep. The increased levels of serotonin, tryptophan, and taurine may explain the antidepressive effect of acute sleep deprivation and deserve further study. This report, to our knowledge the first of metabolic profiling during sleep and sleep deprivation and characterization of 24 h rhythms under these conditions, offers a novel view of human sleep/wake regulation.

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