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JCO:乳制品或可延长结肠癌患者生存

来源:生物谷 2014-06-29 13:15

2014年6月29日讯 /生物谷BIOON/--一项新的研究表明:饮食中富含奶制品可能会稍微延长结肠癌患者生存期。如果大肠癌患者,使用钙和牛奶消耗量可能提高患者生存,但在还没有更多的研究进行确认之前,并不需要改变你的饮食习惯。这项新的研究仅提示了乳品和生存之间的关联,它并没有证明乳制品消耗量是增加寿命的直接原因。

研究员Peter Campbell表示:如果我们的研究结果在今后的研究中被重复,我们可能会看到癌症幸存者饮食指导的变化:病人可能会鼓励增加钙和牛奶的摄入量。

该报告发表在Journal of Clinical Oncology杂志上。在这项研究中,研究小组收集了1992年和2009年间近2300名未扩散的大肠结肠癌患者的数据。到2010年,在这些研究中,949例患者死亡,408死于他们的癌症。研究人员发现,那些吃最多乳制品的患者生存稍长。此外,那些喝牛奶的患者(因其它任何原因死亡)的风险降低28%。

这项研究的作者认为,生存获益可能与乳制品中钙有关,而不是维生素D。他们还提示,钙质可能会阻碍癌症细胞生长及其抑制癌细胞扩散转移至远端组织的能力。(生物谷Bioon.com)

Calcium, Vitamin D, Dairy Products, and Mortality Among Colorectal Cancer Survivors: The Cancer Prevention Study-II Nutrition Cohort

Baiyu Yang, Marjorie L. McCullough, Susan M. Gapstur, Eric J. Jacobs, Roberd M. Bostick, Veronika Fedirko, W. Dana Flanders and

Purpose Higher calcium, vitamin D, and dairy product intakes are associated with lower colorectal cancer incidence, but their impacts on colorectal cancer survival are unclear. We evaluated associations of calcium, vitamin D, and dairy product intakes before and after colorectal cancer diagnosis with all-cause and colorectal cancer-specific mortality among colorectal cancer patients.

Patients and Methods This analysis included 2,284 participants in a prospective cohort who were diagnosed with invasive, nonmetastatic colorectal cancer after baseline (1992 or 1993) and up to 2009. Mortality follow-up was through 2010. Prediagnosis risk factor information was collected on the baseline questionnaire. Postdiagnosis information was collected via questionnaires in 1999 and 2003 and was available for 1,111 patients.

Results A total of 949 participants with colorectal cancer died during follow-up, including 408 from colorectal cancer. In multivariable-adjusted Cox proportional hazards regression models, postdiagnosis total calcium intake was inversely associated with all-cause mortality (relative risk [RR] for those in the highest relative to the lowest quartiles, 0.72; 95% CI, 0.53-0.98; Ptrend = .02) and associated with marginally statistically significant reduced colorectal cancer-specific mortality (RR, 0.59; 95% CI, 0.33 to 1.05; Ptrend = .01). An inverse association with all-cause mortality was also observed for postdiagnosis milk intake (RR, 0.72; 95% CI, 0.55 to 0.94; Ptrend = .02), but not vitamin D intake. Prediagnosis calcium, vitamin D, and dairy product intakes were not associated with any mortality outcomes.

Conclusion Higher postdiagnosis intakes of total calcium and milk may be associated with lower risk of death among patients with nonmetastatic colorectal cancer.

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