打开APP

JACI:特殊细菌保护幼儿免于哮喘症

  1. 哮喘症
  2. 幼儿
  3. 暴露
  4. 细菌

来源:生物谷 2014-06-10 09:10

近日,一项刊登于国际杂志Journal of Allergy and Clinical Immunology上的研究论文中,来自加州大学旧金山分校的科学家通过研究发现,出生一年内暴露于室内灰尘多种细菌中的婴儿或许在其幼童时期患哮喘症的风险较低。

2014年6月10日 讯 /生物谷BIOON/ --近日,一项刊登于国际杂志Journal of Allergy and Clinical Immunology上的研究论文中,来自加州大学旧金山分校的科学家通过研究发现,出生一年内暴露于室内灰尘多种细菌中的婴儿或许在其幼童时期患哮喘症的风险较低。

既不患过敏症又不患哮喘症的三岁儿童很有可能是出生时经常暴露于高水平的细菌中,遭遇了较高水平的常见过敏原而致;该项研究中研究者表示,早期的过敏症状和气喘症疾病是引发儿童幼年期患哮喘症的两大主要风险因子,而在个体生命早期特定过敏原和细菌的伴随暴露对于个体的机体健康反而是有益的。

研究者Boushey指出,增加低风险细菌的多样性和水平似乎从表面上来讲是支持“卫生保健假说”的,这就表明现代西方世界过敏原流行和哮喘症的增加或许是个体幼年时期接触较少细菌而导致的非故意的结果。

研究者Lynch教授表示,暴露于特定细菌中和较低风险的哮喘症,并没有明显的机制可以解释这两者之间的关系,但是很多研究证据都指出微生物对塑造个体后天免疫反应的影响和重要性。研究者希望通过后期更为深入的研究来揭示微生物(肠道微生物)抑制个体哮喘症和过敏症发生的机制。(生物谷Bioon.com)

Effects of early-life exposure to allergens and bacteria on recurrent wheeze and atopy in urban children

Susan V. Lynch, PhD, Robert A. Wood, MD, Homer Boushey, MD, Leonard B. Bacharier, MD, Gordon R. Bloomberg, MD, Meyer Kattan, MD, George T. O’Connor, MD, Megan T. Sandel, MD, Agustin Calatroni, MS, Elizabeth Matsui, MD, Christine C. Johnson, PhD, Henry Lynn, PhD, Cynthia M. Visness, PhD, Katy F. Jaffee, MS, Peter J. Gergen, MD, Diane R. Gold, MD, MPH, Rosalind J. Wright, MD, MPH, Kei Fujimura, PhD, Marcus Rauch, PhD, William W. Busse, MD, James E. Gern, MD

Background Wheezing illnesses cause major morbidity in infants and are frequent precursors to asthma. Objective We sought to examine environmental factors associated with recurrent wheezing in inner-city environments. Methods The Urban Environment and Childhood Asthma study examined a birth cohort at high risk for asthma (n = 560) in Baltimore, Boston, New York, and St Louis. Environmental assessments included allergen exposure and, in a nested case-control study of 104 children, the bacterial content of house dust collected in the first year of life. Associations were determined among environmental factors, aeroallergen sensitization, and recurrent wheezing at age 3 years. Results Cumulative allergen exposure over the first 3 years was associated with allergic sensitization, and sensitization at age 3 years was related to recurrent wheeze. In contrast, first-year exposure to cockroach, mouse, and cat allergens was negatively associated with recurrent wheeze (odds ratio, 0.60, 0.65, and 0.75, respectively; P ≤ .01). Differences in house dust bacterial content in the first year, especially reduced exposure to specific Firmicutes and Bacteriodetes, was associated with atopy and atopic wheeze. Exposure to high levels of both allergens and this subset of bacteria in the first year of life was most common among children without atopy or wheeze. Conclusions In inner-city environments children with the highest exposure to specific allergens and bacteria during their first year were least likely to have recurrent wheeze and allergic sensitization. These findings suggest that concomitant exposure to high levels of certain allergens and bacteria in early life might be beneficial and suggest new preventive strategies for wheezing and allergic diseases.

版权声明 本网站所有注明“来源:生物谷”或“来源:bioon”的文字、图片和音视频资料,版权均属于生物谷网站所有。非经授权,任何媒体、网站或个人不得转载,否则将追究法律责任。取得书面授权转载时,须注明“来源:生物谷”。其它来源的文章系转载文章,本网所有转载文章系出于传递更多信息之目的,转载内容不代表本站立场。不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。

87%用户都在用生物谷APP 随时阅读、评论、分享交流 请扫描二维码下载->