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PLoS ONE:服用抗精神病药物或可影响孕妇所生婴儿的健康状况

  1. 健康状况
  2. 婴儿
  3. 孕妇
  4. 抗精神病药物

来源:生物谷 2014-06-06 09:06

近日,一项刊登在国际杂志PLoS ONE上的研究论文中,来自澳洲莫纳斯大学的科学家通过对服用抗精神病药物的孕妇进行长达7年的研究发现,服用抗精神病药物可以影响其胎儿的健康。

2014年6月6日讯 /生物谷BIOON/ --近日,一项刊登在国际杂志PLoS ONE上的研究论文中,来自澳洲莫纳斯大学的科学家通过对服用抗精神病药物的孕妇进行长达7年的研究发现,服用抗精神病药物可以影响其胎儿的健康。

大部分的妇女可以生出健康的婴儿,怀孕期间孕妇高剂量抗精神病药的服用会增加婴儿在特护婴儿室或新生儿重症监护治疗病房进行特殊照顾的风险为43%;研究者表示,抗精神病药物可以以其它途径来影响胎儿,18%的婴儿会出现早产,37%的婴儿会表现出呼吸困难,15%的婴儿会表现出戒断症状。

Kulkarni教授说道,孕妇怀孕期间抗精神病药物的相关研究非常少,临床上数据的缺少使得研究人员很难为临床医生提供数据供其参考,来对孕妇用药。抗精神病药物当前用于治疗一系列精神疾病包括精神分裂症、严重抑郁以及双相情感障碍等,大约20%的澳大利亚妇女在其一生之中都会患上抑郁症,而男性比例则为10%。25%的女性会患上产后抑郁症,而20%的女性则会经历严重的绝经期抑郁症。

研究者表示,孕妇在服用抗精神病药物时候,应该权衡一下其所带来的潜在危害和不服用药物而导致的精神疾病所带来的危害,目前研究者并不知道特殊的先天性异常和这些药物之间的明确关系;然而临床医生们必须密切关注新生儿的健康状况,比如呼吸性窘迫症等。(生物谷Bioon.com)

A Prospective Cohort Study of Antipsychotic Medications in Pregnancy: The First 147 Pregnancies and 100 One Year Old Babies

Kulkarni J, Worsley R, Gilbert H, Gavrilidis E, Van Rheenen TE, et al.

Background Many women diagnosed with varying psychiatric disorders take antipsychotic medications during pregnancy. The safety of antipsychotic medications in pregnancy is largely unknown. Methods We established the National Register of Antipsychotic Medications in Pregnancy in 2005. Women who are pregnant and taking an antipsychotic medication are interviewed every 6 weeks during pregnancy and then followed until their babies are one year old. The baby's progress is closely followed for the first year of life. Findings As of April 18 2012, 147 pregnancies had been followed through to completion. There were 142 live births and data is available for 100 one year old babies. 18% of babies were born preterm, with a higher dose of antipsychotic medication correlating to an increased likelihood of premature delivery; 43% of babies required special care nursery or intensive care after birth; 37% had any degree of respiratory distress and 15% of babies developed withdrawal symptoms. Congenital anomalies were seen in eight babies. Most pregnancies resulted in the birth of live, healthy babies. The use of mood stabilisers or higher doses of antipsychotics during pregnancy increased the likelihood of babies experiencing respiratory distress or admission to Special Care Nursery or Neonatal Intensive Care Units. Conclusion There is a great need for safety and efficacy information about the use of antipsychotic medications in pregnancy. Live, healthy babies are the most common outcome following the use of antipsychotic medication in pregnancy, but clinicians should be particularly mindful of neonatal problems such as respiratory distress.

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