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PLoS ONE:科学家发现身材矮小的男性寿命更长

  1. 寿命
  2. 男性
  3. 矮小
  4. 身材

来源:生物谷 2016-03-23 14:52

近日,刊登在国际杂志PLoS One上的一篇研究论文中,来自夏威夷大学的研究人员通过研究发现,在日本男性中矮小的身材和较长的寿命存在之间关联;研究者Bradley Willcox教授表示,我们可以将人类分为两种:身高5英尺2寸以下和5英尺2寸以上的两类,身高5英尺2寸以下的人们的寿命可以更长一些,而且个体身高越高其寿命越短。

2014年5月10日 讯 /生物谷BIOON/ --近日,刊登在国际杂志PLoS One上的一篇研究论文中,来自夏威夷大学的研究人员通过研究发现,在日本男性中矮小的身材和较长的寿命存在之间关联;研究者Bradley Willcox教授表示,我们可以将人类分为两种:身高5英尺2寸以下和5英尺2寸以上的两类,身高5英尺2寸以下的人们的寿命可以更长一些,而且个体身高越高其寿命越短。

研究者说道,矮个儿男性或许机体中更易出现保护性的长寿基因FOXO3,从而在早期发育和生活中导致身材尺寸更小,而且矮个儿男性血液中的胰岛素水平较低,患癌风险也较低;Willcox博士表示,这项研究中我们首次研究揭示身材尺寸和基因直接相关,此前我们只知道在动物模型中存在这样的关联,但是如今我们利用小鼠、蠕虫等进行研究发现身材尺寸和个体的寿命直接关联。

研究者并未指出特殊的身高或者年龄范围,部分是因为不管你多高,你依然可以保持健康的生活方式,或许这些人机体中会存在FOXO3的基因型但并不是用于增加寿命的基因类型。本文研究在一定范围内对于揭示身高和寿命之间的关联提供了一定的研究数据。

最后研究者表示,我们在1965年对8006名在1900年至1919年出生的个体进行研究,研究中大约1200名男性基本都活到了90多岁,甚至100多岁,而且有将近250人至今一直健康生活着。(生物谷Bioon.com)

 

Shorter Men Live Longer: Association of Height with Longevity and FOXO3 Genotype in American Men of Japanese Ancestry

He Q, Morris BJ, Grove JS, Petrovitch H, Ross W, et al.

 

Objectives To determine the relation between height, FOXO3 genotype and age of death in humans. Methods Observational study of 8,003 American men of Japanese ancestry from the Honolulu Heart Program/Honolulu-Asia Aging Study (HHP/HAAS), a genetically and culturally homogeneous cohort followed for over 40 years. A Cox regression model with age as the time scale, stratified by year of birth, was used to estimate the effect of baseline height on mortality during follow-up. An analysis of height and longevity-associated variants of the key regulatory gene in the insulin/IGF-1 signaling (IIS) pathway, FOXO3, was performed in a HHP-HAAS subpopulation. A study of fasting insulin level and height was conducted in another HHP-HAAS subpopulation. Results A positive association was found between baseline height and all-cause mortality (RR = 1.007; 95% CI 1.003–1.011; P = 0.002) over the follow-up period. Adjustments for possible confounding variables reduced this association only slightly (RR = 1.006; 95% CI 1.002–1.010; P = 0.007). In addition, height was positively associated with all cancer mortality and mortality from cancer unrelated to smoking. A Cox regression model with time-dependent covariates showed that relative risk for baseline height on mortality increased as the population aged. Comparison of genotypes of a longevity-associated single nucleotide polymorphism in FOXO3 showed that the longevity allele was inversely associated with height. This finding was consistent with prior findings in model organisms of aging. Height was also positively associated with fasting blood insulin level, a risk factor for mortality. Regression analysis of fasting insulin level (mIU/L) on height (cm) adjusting for the age both data were collected yielded a regression coefficient of 0.26 (95% CI 0.10–0.42; P = 0.001). Conclusion Height in mid-life is positively associated with mortality, with shorter stature predicting longer lifespan. Height was, moreover, associated with fasting insulin level and the longevity genotype of FOXO3, consistent with a mechanistic role for the IIS pathway.

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