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BJUI:睾丸激素水平低预示前列腺癌恶化

  1. 前列腺癌
  2. 睾丸激素

来源:生物谷 2014-05-06 13:27

根据发表在BJU International杂志上的一项新研究得出的结论:对于前列腺癌低风险的男性来说,睾丸激素水平低可能表明前列腺癌疾病会恶化。这一发现可帮助医生确定前列腺癌低风险者中谁应该接受积极的抗癌治疗。有前

2014年5月6日讯 /生物谷BIOON/--根据发表在BJU International杂志上的一项新研究得出的结论:对于前列腺癌低风险的男性来说,睾丸激素水平低可能表明前列腺癌疾病会恶化。这一发现可帮助医生确定前列腺癌低风险者中谁应该接受积极的抗癌治疗。

有前列腺癌风险的男性需要进行主动监测,这包括密切监测以确保他们的前列腺疾病不会成为严重,危害他们健康的疾病。不幸的是目前,医生在主动监测期间没有可靠的方法预测哪些男性会发展恶化或更严重的疾病。

Ignacio San Francisco医学博士和他的同事们探究发现睾丸激素水平可能提供预示迹象。新研究针对154名前列腺癌低风险男性开展38个月的研究后,研究者发现,游离睾酮水平低显著与发展更严重疾病风险增加相关。他们发现,总睾酮浓度与发展更严重疾病风险增加没有显著关联。

这些结果表明睾丸激素水平低与更积极的前列腺癌相关。这与长期持有的信念一致,高睾酮是前列腺癌的危险因素,睾丸激素水平低可起到保护效应。(生物谷Bioon.com)

 

 

Low free testosterone predicts disease reclassification in men with prostate cancer undergoing active surveillance

Ignacio F. San Francisco, Pablo A. Rojas, William C. DeWolf, Abraham Morgentaler.

Objective
To determine whether total testosterone and free testosterone levels predict disease reclassification in a cohort of men with prostate cancer (PCa) on active surveillance (AS).

Patients and Methods
Total testosterone and free testosterone concentrations were determined at the time the men began the AS protocol. Statistical analysis was performed using Student's t-test and a chi-squared test to compare groups. Odds ratios (ORs) with 95% confidence intervals (CIs) were obtained using univariate logistic regression. Receiver–operator characteristic curves were generated to determine the investigated testosterone thresholds. Kaplan–Meier curves were used to estimate time to disease reclassification. A Cox proportional hazard regression model was used for multivariate analysis.

Results
A total of 154 men were included in the AS cohort, of whom 54 (35%) progressed to active treatment. Men who had disease reclassification had significantly lower free testosterone levels than those who were not reclassified (0.75 vs 1.02 ng/dL, P = 0.03). Men with free testosterone levels <0.45 ng/dL had a higher rate of disease reclassification than patients with free testosterone levels ≥0.45 (P = 0.032). Free testosterone levels <0.45 ng/dL were associated with a several-fold increase in the risk of disease reclassification (OR 4.3, 95% CI 1.25–14.73). Multivariate analysis showed that free testosterone and family history of PCa were independent predictors of disease reclassification.

Conclusions
Free testosterone levels were lower in men with PCa who had reclassification during AS. Men with moderately severe reductions in free testosterone level are at increased risk of disease reclassification.

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