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Psychiat Res: 帕金森氏症伴发抑郁症不容忽视

来源:生物谷 2014-04-21 13:15

2014年4月21日讯 /生物谷BIOON/--近日,来自肯塔基大学科学家对帕金森氏病(PD)的抑郁症和神经心理功能开展了研究。相关研究成果发表在杂志Psychiatry Research上,研究评估了抑郁和非抑郁PD患者的认知功能。

研究发现对于抑郁帕金森患者,常用来治疗帕金森病运动症状的多巴胺替代疗法与此类患者认知能力的下降相关。

相比之下,多巴胺替代疗法改善非抑郁帕金森病患者的认知功能。该研究还发现,在多巴胺能药物治疗中,情绪抑郁帕金森氏症患者实际上表现的更糟。

这项研究的首席研究员Lee Blonder博士表示,这是一个惊喜,这与我们原来的假设(即多巴胺能药物能改善两组PD患者的认知能力)相反,而且原来假设抑郁PD组心情也将有所改善。

28例PD患者中,18例非抑郁患者和10例抑郁患者,被赋予了一系列基线测试,以评估认知功能和抑郁的发生率和严重程度。然后,他们在接受或未接受多巴胺替代疗法后被重新测试。

结果显示,在所有情况下,抑郁帕金森氏症患者接受多巴胺能药物后认知功能显著表现的更差。抑郁症是帕金森氏患者一种常见的严重合并症,研究表明,大约40%的PD患者患有抑郁症。

Blonder警告说,这些结果在一定程度上是初步的,由于只有28人参加实验。这些结果应用于改变治疗计划之前,需要更多的研究,Blonder说:不过,未来的研究应最终着眼于调查帕金森氏症抑郁症患者的治疗方案,以最大限度地提高患者的认知功能而不会影响他们的心理健康。(生物谷Bioon.com)

 

Dopaminergic modulation of memory and affective processing in Parkinson depression

Lee X. Blonder,et al.

Depression is common in Parkinson's disease and is associated with cognitive impairment. Dopaminergic medications are effective in treating the motor symptoms of Parkinson's disease; however, little is known regarding the effects of dopaminergic pharmacotherapy on cognitive function in depressed Parkinson patients. This study examines the neuropsychological effects of dopaminergic pharmacotherapy in Parkinsonian depression. We compared cognitive function in depressed and non-depressed Parkinson patients at two time-points: following overnight withdrawal and after the usual morning regimen of dopaminergic medications. A total of 28 non-demented, right-handed patients with mild to moderate idiopathic Parkinson's disease participated. Ten of these patients were depressed according to DSM IV criteria. Results revealed a statistically significant interaction between depression and medication status on three measures of verbal memory and a facial affect naming task. In all cases, depressed Parkinson's patients performed significantly more poorly while on dopaminergic medication than while off. The opposite pattern emerged for the non-depressed Parkinson's group. The administration of dopaminergic medication to depressed Parkinson patients may carry unintended risks.

 

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