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Cancer Epidem Biomar:研究发现慢性炎症与前列腺癌的相关性

  1. 前列腺癌
  2. 慢性炎症

来源:生物谷 2014-04-21 13:29

2014年4月18日讯 /生物谷BIOON/--根据约翰霍普金斯大学Kimmel癌症中心研究人员一项新的研究证实:非癌性前列腺组织中表现有慢性炎症迹象的男子,实际上可能比那些没有炎症迹象的男子患前列腺癌的几率高出近两倍的风险。持续性炎症和癌症之间的联系在恶性前列腺癌中是更明显。研究人员一直在观察研究前列腺炎症和前列腺癌之间明显的联系,但一直不能证明炎症是前列腺癌的一个原因。

2014年4月18日讯 /生物谷BIOON/--根据约翰霍普金斯大学Kimmel癌症中心研究人员一项新的研究证实:非癌性前列腺组织中表现有慢性炎症迹象的男子,实际上可能比那些没有炎症迹象的男子患前列腺癌的几率高出近两倍的风险。

持续性炎症和癌症之间的联系在恶性前列腺癌中是更明显。研究人员一直在观察研究前列腺炎症和前列腺癌之间明显的联系,但一直不能证明炎症是前列腺癌的一个原因。癌症研究人员Angelo M. De Marzo医学博士警告说,炎症在男性中是太普遍的,被作为前列腺癌的诊断工具。然而,研究人员想知道更多关于什么原因导致前列腺发炎,怎么可能导致前列腺癌,并且这种炎症是否可能会被阻止。我认为防止炎症或当它发生时介入,对癌症治疗会有战略性进展。

结果发表在Cancer Epidemiology, Biomarkers & Prevention杂志上。研究人员已经在其他研究中研究炎症与前列腺癌之间的可能联系,但以往的研究只是采样经过活检手术男性的组织,Platz解释:我们的研究旨在排除,前列腺癌检测方法和判断炎症存在之间通常存在的偏见。

由于炎症致使PSA水平提高,男性发生炎症后更可能有较高的PSA,PSA上升,他们更可能进一步的进行切片检查,通过做更多的活组织切片检查这些人,前列腺癌是更容易被检测到的,即使炎症不是前列腺癌的原因。

在这项研究中,Platz, De Marzo和同事研究了191名前列腺癌和209无癌者的活检组织样本,检查样本炎症反应的发生率和程度。他们发现86.2%的前列腺癌患者至少有一个组织样品中显示炎症迹象,而这一比例在无癌男性中为78.2%。

De Marzo说,我们认为前列腺炎症在活检男性(因为较高PSA水平和前列腺癌其他等指标)中是很常见的,但我们没有预料到前列腺炎症在没有迹象预示要活检的男性中也具有高患病率。

美国约翰霍普金斯大学研究小组正在研究没有迹象表明要进行前列腺活检的男性中,PSA水平和炎症之间的关系,以及性传播疾病史和前列腺炎症程度之间的潜在联系。(生物谷Bioon.com)

 

Chronic Inflammation in Benign Prostate Tissue Is Associated with High-Grade Prostate Cancer in the Placebo Arm of the Prostate Cancer Prevention Trial

Bora Gurel, M. et al.

Background: Chronic inflammation is hypothesized to influence prostate cancer development, although a definitive link has not been established.

Methods: Prostate cancer cases (N = 191) detected on a for-cause (clinically indicated) or end-of-study (protocol directed) biopsy, and frequency-matched controls (N = 209), defined as negative for cancer on an end-of-study biopsy, were sampled from the placebo arm of the Prostate Cancer Prevention Trial. Inflammation prevalence and extent in benign areas of biopsy cores were visually assessed using digital images of hematoxylin and eosin–stained sections. Logistic regression was used to estimate associations.

Results: Of note, 86.2% of cases and 78.2% of controls had at least one biopsy core (of three assessed) with inflammation in benign areas, most of which was chronic. Men who had at least one biopsy core with inflammation had 1.78 [95% confidence interval (CI), 1.04–3.06] times the odds of prostate cancer compared with men who had zero cores with inflammation. The association was stronger for high-grade disease (Gleason sum 7–10, N = 94; OR, 2.24; 95% CI, 1.06–4.71). These patterns were present when restricting to cases and controls in whom intraprostatic inflammation was the least likely to have influenced biopsy recommendation because their prostate-specific antigen (PSA) was low (<2 ng/mL at biopsy).

Conclusion: Inflammation, most of which was chronic, was common in benign prostate tissue, and was positively associated with prostate cancer, especially high grade. The association did not seem to be due to detection bias.

Impact: This study supports an etiologic link between inflammation and prostate carcinogenesis, and suggests an avenue for prevention by mitigating intraprostatic inflammation.

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