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Circ Heart Failure:乐观心态或可降低个体心力衰竭的风险

来源:生物谷 2014-04-10 23:44

2014年4月10日 讯 /生物谷BIOON/ --近日,来自哈佛大学等处的研究人员通过研究表明,乐观的老年个体或许患心力衰竭的风险较低,相关研究刊登于国际杂志Circulation:Heart Failure上。

文章中,研究者发现乐观可以明显降低50岁老年人患心衰的风险,相比最小乐观度的个体来讲,最为乐观的个体心衰风险可以降低73%的比例;Eric Kim博士表示,这项研究中我们对6808名年龄在50岁及以上的老年个体进行为期4年的跟踪研究,为揭示这些个体的健康历史以及心理数据提供了很好的基础。

为了排除其它因子对揭示乐观和心衰风险关系的影响,研究者调整了可能影响个体心衰风险的因子,包括人口统计学因素、健康行为、慢性疾病和生化因子等;研究期间研究者发现,越乐观的个体其心衰风险越低,这就为开发新型策略来帮助改善个体的心力衰竭风险提供了一定的思路。

此前研究中研究者揭示了乐观对机体的保护效应,比如乐观和个体的某些健康行为(饮食行为、锻炼行为)有关,本文的研究中研究者又得到了新的发现,这将为降低患病老年个体心力衰竭的风险提供一定帮助。(生物谷Bioon.com)

doi:10.1161/​CIRCHEARTFAILURE.113.000644
A Prospective Study of the Association Between Dispositional Optimism and Incident Heart Failure

Eric S. Kim1*, Jacqui Smith2 and Laura D. Kubzansky3

Background—Although higher optimism has been linked with an array of positive health behaviors, biological processes, and cardiovascular outcomes, the relationship between optimism and heart failure has not been examined. In the United States, 80% of heart failures occur in adults aged 65+. Therefore, we examined whether higher optimism was linked with a reduced incidence of heart failure among older adults. Methods and Results—Prospective data were from the Health and Retirement Study, a nationally representative study of older U.S adults. Our sample included 6,808 participants who were followed for four years. Multiple logistic regression models were used to assess if optimism was independently associated with incident heart failure. We adjusted for sociodemographic, behavioral, biological, and psychological covariates. Higher optimism was associated with a lower risk of incident heart failure over the follow-up period. In a model that adjusted for sociodemographic factors, each standard deviation increase in optimism had an odds ratio of 0.74 (95% CI, 0.63-0.85) for heart failure. Effects of optimism persisted even after adjusting for a wide range of covariates. There was also evidence of a dose-response relationship. As optimism increased, risk of developing heart failure decreased monotonically, with a 48% reduced odds among people with the highest versus lowest optimism. Conclusions—This is the first study to suggest that optimism is associated with a lower risk of heart failure. If future studies confirm these findings, they may be used to inform new strategies for preventing or delaying the onset of heart failure.

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