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BMJ:抗焦虑药物和安眠药或和个体高风险死亡直接相关

  1. BMJ
  2. 安眠药
  3. 抗焦虑药
  4. 死亡

来源:生物谷 2014-04-01 23:33

近日,刊登在国际杂志BMJ上的一篇研究论文中,来自华威大学的研究人员通过研究表示,抗焦虑药物和安眠药或许和个体的死亡风险增加直接相关,这些药物会增加一倍个体的死亡风险。

2014年4月1日 讯 /生物谷BIOON/ --近日,刊登在国际杂志BMJ上的一篇研究论文中,来自华威大学的研究人员通过研究表示,抗焦虑药物和安眠药或许和个体的死亡风险增加直接相关,这些药物会增加一倍个体的死亡风险。

研究者Scott Weich教授解释道,关键是我们在日常生活中使用这些药物时要特别注意,我们的研究已经证实了抗焦虑药物和安眠药的副作用以及危险性,因此我们必须尽可能减少对抗焦虑剂以及安眠药的使用量以及依赖性。

当然这并不表示抗焦虑药物和安眠药并没有有效的作用,这主要取决于病人个体的用途,比如对于进行认知行为治疗的个体来讲,这些药物就可以帮助其克服焦虑和睡眠的问题。研究者表示,当然还必须考虑个体的年龄、吸烟状况以及酗酒情况,还应该对其它风险因子比如睡眠障碍、焦虑障碍以及其它精神疾病个体进行有效的药物服用控制。

本文的研究结论是研究者主要对34,727名个体进行了平均7.5年的研究所得出的,研究期间研究者对参与者单一服用抗焦虑药或者服用催眠药,本文的研究对于有效控制个体抗焦虑药物或安眠药摄入提供了一定的基础,也为降低个体因服用抗焦虑药物死亡的风险提供了一定的研究思路。(生物谷Bioon.com)

doi:10.1136/bmj.g1996
Effect of anxiolytic and hypnotic drug prescriptions on mortality hazards: retrospective cohort study

Scott Weich, professor of psychiatry1, Hannah Louise Pearce, prescribing and public health analyst2, Peter Croft, professor of primary care epidemiology3, Swaran Singh, professor of social and community psychiatry1, Ilana Crome, professor of addiction psychiatry4, James Bashford, lecturer in primary care research2, Martin Frisher, reader in health services research2

Objective To test the hypothesis that people taking anxiolytic and hypnotic drugs are at increased risk of premature mortality, using primary care prescription records and after adjusting for a wide range of potential confounders. Design Retrospective cohort study. Setting 273 UK primary care practices contributing data to the General Practice Research Database. Participants 34 727 patients aged 16 years and older first prescribed anxiolytic or hypnotic drugs, or both, between 1998 and 2001, and 69 418 patients with no prescriptions for such drugs (controls) matched by age, sex, and practice. Patients were followed-up for a mean of 7.6 years (range 0.1-13.4 years). Main outcome All cause mortality ascertained from practice records. Results Physical and psychiatric comorbidities and prescribing of non-study drugs were significantly more prevalent among those prescribed study drugs than among controls. The age adjusted hazard ratio for mortality during the whole follow-up period for use of any study drug in the first year after recruitment was 3.46 (95% confidence interval 3.34 to 3.59) and 3.32 (3.19 to 3.45) after adjusting for other potential confounders. Dose-response associations were found for all three classes of study drugs (benzodiazepines, Z drugs (zaleplon, zolpidem, and zopiclone), and other drugs). After excluding deaths in the first year, there were approximately four excess deaths linked to drug use per 100 people followed for an average of 7.6 years after their first prescription. Conclusions In this large cohort of patients attending UK primary care, anxiolytic and hypnotic drugs were associated with significantly increased risk of mortality over a seven year period, after adjusting for a range of potential confounders. As with all observational findings, however, these results are prone to bias arising from unmeasured and residual confounding.

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