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PLoS ONE:鉴别出和非结核分枝杆菌引发的肺部感染相关的风险因子

来源:生物谷 2014-03-20 23:36

2014年3月21日 讯 /生物谷BIOON/ --近日,来自伊利诺伊大学的研究者通过研究表明,和引发肺结核疾病相同家族的分枝杆菌往往引发致死性的肺部疾病或许更为普遍一点,相关研究刊登于国际杂志PLoS One上。

非结核分枝杆菌(NTM)包括150多种细菌,其遍布于水中、土壤中,可以通过呼吸感染人类肺部组织,NTM并不像结核分枝杆菌那样,其不会通过接触传染,也不能经人传播,而且其引发的感染是可以治疗的,但是抗生素疗法很长昂贵,而且需要长期服药长达2年以上。

研究者Mehdi Mirsaeidi表示,很多研究都表明由NTM引发的肺部感染的趋势在北美正在不断上升,尤其是在50岁以上的老年个体中;我们想知道引发NTM感染的主要风险因子,这样我们就可以开发合适的疗法来抑制NTM的感染。

文章中研究者对1999年之2010年间美国因NTM感染死亡的病例进行分析研究,发现NTM是2990人直接感染死亡的主要原因,其中87%的人群年龄都在55岁以上,85%的人群为白人,52%的人群为女性。研究者表示,年龄相适应的NTM致死率在美国夏威夷居民中是不均衡的,但是究其原因尚不清楚。

同时NTM相关的死亡和吸烟、癌症、HIV感染以及慢阻肺直接相关;但是NTM疾病死亡和老年化之间却存在强相关的关系,Mirsaeidi表示,患者和医生们都需要关注NTM的感染,当然深入研究理解和NTM感染相关的风险因子对于开发有效的疗法以及新型诊断技术非常关键。(生物谷Bioon.com)

Nontuberculous Mycobacterial Disease Mortality in the United States, 1999–2010: A Population-Based Comparative Study

Mirsaeidi M, Machado RF, Garcia JGN, Schraufnagel DE

Background Environmental nontuberculous mycobacteria (NTM) are ubiquitous organisms with which humans commonly interact. The epidemiologic characteristics of NTM diseases including mortality rate and its associated factors remain largely unknown. In this study, we explored the geographical area of exposure and mortality and comorbid conditions of affected persons to determine environment, host, and host-pathogen interactive factors. Methods We analyzed mortality related to nontuberculous mycobacterial infections from 1999 through 2010 by examining multiple-cause-of-death data from the National Center for Health Statistics. Among those who died with these diseases, we analyzed age-adjusted mortality rates, trends, associations with demographic variables, and comorbid conditions and correlated this information with similar data for tuberculosis-related mortality during the same time. Measurements and Mean Results From 1999 through 2010, nontuberculous mycobacterial disease was reported as an immediate cause of death in 2,990 people in the United States with a combined overall mean age-adjusted mortality rate of 0.1 per 100,000 person-years. A significant increase in the number of NTM related deaths was seen from 1999 through 2010 (R2 = 0.72, p<0.0001), but it was not significant after adjustment for age. Persons aged 55 years and older, women, those living in Hawaii and Louisiana, and those of non-Hispanic, white ethnicity had higher mortality rates. Compared to tuberculosis-related mortality, chronic obstructive pulmonary disease, bronchiectasis, HIV, interstitial lung diseases, and tobacco use were significantly more common in persons with nontuberculous mycobacteria-related deaths. Conclusions Nontuberculous mycobacteria-related death numbers are rising and are unevenly distributed. The strong association of nontuberculous mycobacterial disease with age suggests that its prevalence will increase as the United States population ages.

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