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PNAS:促进肠道微生物群从而减少小鼠的结肠炎

来源:EurekAlert 2014-03-18 09:29

一项研究说,与对照组的小鼠相比,缺乏tmf1基因的小鼠在肠道产生了更厚、更健壮的粘液层,促进了益生菌的定植和生长,并且增加了对诱导产生的结肠炎的抵抗,这些小鼠可以把这种抵抗传给拥有这种基因的其他小鼠。(生物谷Bioon.com)

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Proceedings of the National Academy of the Sciences of the United States of America         doi: 10.1073/pnas.1319114111

Reprogrammed and transmissible intestinal microbiota confer diminished susceptibility to induced colitis in TMF/ mice

Shai Bela, Yoav Elkisa, Hila Elifantza, Omry Korenb, Rotem Ben-Hamoa, Tal Lerer-Goldshteina, Roni Rahimia, Shomron Ben Horinc, Abraham Nyskad, Sally Shpungina, and Uri Nira,e,1

Tata Element Modulatory Factor (TMF/ARA160) is a multifunctional Golgi-associated protein, which accumulates in colonic enterocytes and goblet cells. Mice lacking TMF/ARA160 (TMF/) produce thick and uniform colonic mucus that resists adherent bacterial colonization and diminishes susceptibility of these mice to induced acute colitis, through a mechanism that is not fully understood. Here, we show that mucus secretion by goblet cells is altered in the colon of TMF/ mice, resulting in the formation of a highly oligomerized colonic gel-forming mucin, MUC2. Microbiome analysis revealed a shift in the microbiota of TMF/ mice leading to predominance of the Firmicutes phylum and a significantly higher abundance of probiotic beneficial bacterial species. Notably, this trait was transmissible, and when cohoused with wild-type animals, TMF/ mice influenced the microbiota and diminished the susceptibility of wild-type mice to chemically induced dextran sulfate sodium colitis. Thus, altered mucus secretion in TMF/ mouse colons is accompanied by a reprogrammed intestinal microbiota, leading to a transmissible reduced sensitivity to induced colitis.

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