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CMAJ:科学家发现睡眠呼吸暂停的个体或患肺炎的风险较高

  1. 个体
  2. 睡眠呼吸暂停
  3. 肺炎
  4. 风险

来源:生物谷 2014-03-05 23:52

来自台北荣民总医院(Taipei Veterans General Hospital)的研究人员通过研究表示,睡眠呼吸暂停的个体相比正常个体来讲或患肺炎的风险较高。

2014年3月6日 讯 /生物谷BIOON/ --近日,来自台北荣民总医院(Taipei Veterans General Hospital)的研究人员通过研究表示,睡眠呼吸暂停的个体相比正常个体来讲或患肺炎的风险较高,相关研究成果刊登于国际杂志Canadian Medical Association Journal上。

睡眠呼吸暂停主要表现为睡眠经常中断,主要是因为上呼吸道因为软组织阻塞而引发;睡眠呼吸暂停和许多心脏疾病以及认知损伤直接相关,阻塞性睡眠呼吸暂停的个体往往在睡觉时患吸入性肺炎的风险较高。

为了确定是否睡眠呼吸暂停和肺炎的发生相关,研究人员对34100名个体进行了长达11年的追踪调查研究,其中6816名个体患睡眠呼吸暂停,而27284名个体为对照组;通过研究研究者认为,相比对照个体来讲,患睡眠呼吸暂停的个体往往更易发展成为肺炎,而患肺炎的个体年龄较大,而且患有许多共存病,比如心脏疾病、糖尿病、痴呆以及其它疾病等。

研究者Yi-Fong Su表示,这项研究揭示了睡眠呼吸暂停或许是导致偶然肺炎发生的一种风险因子,我们的研究结果表明患有严重睡眠呼吸暂停的病人往往面临患肺炎的风险,当然同时也会引发其它疾病的发生。

近年来许多研究都发现睡眠呼吸暂停和肺炎之间的关系,研究人员表示,那些睡眠呼吸暂停的个体之所以患肺炎或许是因为其喉咙中吸入的内容物或液体引发的风险所致。(生物谷Bioon.com)

doi:10.1503/cmaj.131547
Sleep apnea and risk of pneumonia: a nationwide population-based study

Vincent Yi-Fong Su, Chia-Jen Liu, Hsin-Kai Wang, Li-An Wu, Shi-Chuan Chang, Diahn-Warng Perng, Wei-Juin Su, Yuh-Min Chen, Elizabeth Ya-Hsuan Lin, Tzeng-Ji Chen, Kun-Ta Chou

Background: Evidence evaluating the risk of pneumonia in patients with obstructive sleep apnea is limited and mostly focuses on patients who receive continuous positive airway pressure (CPAP) therapy or on pediatric patients. We aimed to explore the risk of incident pneumonia among adults with sleep apnea, either with or without the need of CPAP therapy. Methods: From Jan. 1, 2000, we identified adult patients with sleep apnea from the Taiwan National Health Insurance Research Database. A control cohort without sleep apnea, matched for age, sex and comorbidities, was selected for comparison. The 2 cohorts were followed until Dec. 31, 2010, and observed for occurrence of pneumonia. Results: Of the 34 100 patients (6816 study patients and 27 284 matched controls), 2757 (8.09%) had pneumonia during a mean followup period of 4.50 years, including 638 (9.36%) study patients and 2119 (7.77%) controls. Kaplan-Meier analysis showed a higher incidence of pneumonia among patients with sleep apnea (log rank test, p < 0.001). After multivariate adjustment, patients with sleep apnea experienced a 1.20-fold (95% confidence interval 1.10-1.31) increase in incident pneumonia. The risk was even higher among patients who received CPAP therapy. Interpretation: Sleep apnea appeared to confer a higher risk for future pneumonia, possibly in a severity-dependent manner.

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