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首页 » 生物研究 » 科学家发现SIRT1蛋白与动物寿命有关

科学家发现SIRT1蛋白与动物寿命有关

来源:生物谷 2014-03-02 19:03

2014年3月2日讯 /生物谷BIOON/ --最近来自美国国家健康中心下属国家老龄化研究中心的Dr. Rafael de Cabo和其研究团队在著名期刊Cell Reports上发表了一项关于一种名为SIRT1蛋白的蛋白质能够延长小鼠寿命的研究结果。此前有研究表明SIRT1蛋白在不同组织中都能表现出延缓衰老的功能,同时能降低一些与年龄相关的慢性疾病发生频率。Dr. Rafael de Cabo等人通过给小鼠添加SIRT1720--一种能够激活SIRT1的小分子物质--发现,当SIRT升高时,小鼠的平均寿命增加了8.8%,同时其体脂含量与体重也都有所降低,肌肉功能等也都有所改善。

Dr. Rafael de Cabo认为这一结果有助于人们对老龄化及老年疾病的进一步认识以及相关疾病疗法的开发。(生物谷Bioon.com)

详细英文报道:

A drug supplement that activates a protein involved in metabolic balance showed an extension in lifespan and improvement in the overall health of mice, according to a new study.

The findings, published Feb. 27 in Cell Reports, may eventually help scientists develop therapies to minimize the effects of age-related metabolic and chronic diseases on the human body.

Researchers, led by Dr. Rafael de Cabo of the National Institute on Aging at the National Institutes of Health, found that activating the protein sirtuin 1 delayed the onset of age-related metabolic diseases. Scientists know that sirtuin 1, or SIRT1, plays an important role in maintaining metabolic balance in multiple tissues. Previous studies have shown that activating this protein can have a myriad of health benefits in different organisms, and drugs that increase SIRT1 activity have been able to slow the onset of aging and delay age-associated diseases in several animal models.

De Cabo and colleagues tested a small molecule that activates SIRT1, called SIRT1720, on mice. They gave the animals a standard diet plus a 100 mg dose of SRT1720 beginning at 6 months of age for the rest of their lives.

The SRT1720 supplement not only extended the average lifespan of mice by 8.8%, but it also reduced body weight and body fat percentage, and improved muscle function and motor coordination throughout the animals' lives, according to the researchers.

"[This research] illustrates that we can develop molecules that ameliorate the burden of metabolic and chronic diseases associated with aging," De Cabo said in a statement.

Further studies by de Cabo and his team revealed that the SRT1720 supplement also helped decrease total cholesterol and LDL-cholesterol levels in mice. High levels of LDL-cholesterol, or "bad" cholesterol, put you at risk for heart disease and diabetes. The researchers found that SIRT1720 also had anti-inflammatory effects in various tissues in the animal subjects.

The research was conducted under a Cooperative Research and Development Agreement (CRADA) between GlaxoSmithKline's ($GSK) now defunct Sirtris and the National Institute on Aging.

 

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