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J Clin Oncol:催眠治疗减少乳腺癌放疗患者疲劳程度

  1. 乳腺癌
  2. 催眠
  3. 放疗
  4. 疲劳

来源:生物谷 2014-02-26 22:20

研究证实:认知行为治疗加催眠(CBTH)可以帮助接受放疗的乳腺癌患者减少疲劳程度。

2014年2月217日讯 /生物谷BIOON/--根据最近发表在Journal of Clinical Oncology杂志上的一项研究证实:认知行为治疗加催眠(CBTH)可以帮助接受放疗的乳腺癌患者减少疲劳程度。

这项有200例患者参与的随机对照试验结果表明,治疗组无论在治疗过程中和之后的长达半年时间内,都比对照组患者的疲劳显著较少。

在放疗结束时,治疗组患者平均比对照组79%的患者疲劳程度少,放疗结束半年后,治疗组的患者平均比对照组95%的患者乏力程度少。这些结果支持CBTH可能成为干预手段,以控制接受放疗的乳腺癌患者的疲劳。

CBTH能减少一些其他治疗方案患者的疲劳,CBTH是无创,无不良副作用,而且它的有利影响在最后介入治疗后会长期存在。此外,病人还报告说,参与CBTH是放松和有益的。

这项研究很重要,因为它提示了一个新的干预,有助于改善乳腺癌放疗期间及之后患者的生活质量。(生物谷Bioon.com)

doi:10.1200/JCO.2013.49.3437
Randomized Controlled Trial of a Cognitive-Behavioral Therapy Plus Hypnosis Intervention to Control Fatigue in Patients Undergoing Radiotherapy for Breast Cancer

Guy H. Montgomery, Daniel David, Maria Kangas, Sheryl Green, Madalina Sucala, Dana H. Bovbjerg, Michael N. Hallquist and

Purpose The objective of this study was to test the efficacy of cognitive-behavioral therapy plus hypnosis (CBTH) to control fatigue in patients with breast cancer undergoing radiotherapy. We hypothesized that patients in the CBTH group receiving radiotherapy would have lower levels of fatigue than patients in an attention control group.

Patients and Methods Patients (n = 200) were randomly assigned to either the CBTH (n = 100; mean age, 55.59 years) or attention control (n = 100; mean age, 55.97 years) group. Fatigue was measured at four time points (baseline, end of radiotherapy, 4 weeks, and 6 months after radiotherapy). Fatigue was measured using the Functional Assessment of Chronic Illness Therapy (FACIT) –Fatigue subscale and Visual Analog Scales (VASs; Fatigue and Muscle Weakness).

Results The CBTH group had significantly lower levels of fatigue (FACIT) at the end of radiotherapy (z, 6.73; P < .001), 4-week follow-up (z, 6.98; P < .001), and 6-month follow-up (z, 7.99; P < .001) assessments. Fatigue VAS scores were significantly lower in the CBTH group at the end of treatment (z, 5.81; P < .001) and at the 6-month follow-up (z, 4.56; P < .001), but not at the 4-week follow-up (P < .07). Muscle Weakness VAS scores were significantly lower in the CBTH group at the end of treatment (z, 9.30; P < .001) and at the 6-month follow-up (z, 3.10; P < .02), but not at the 4-week follow-up (P < .13).

Conclusion The results support CBTH as an evidence-based intervention to control fatigue in patients undergoing radiotherapy for breast cancer. CBTH is noninvasive, has no adverse effects, and its beneficial effects persist long after the last intervention session. CBTH seems to be a candidate for future dissemination and implementation.

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