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Angew Chem:研究发现降低化疗药物顺铂副作用的前体药物

来源:生物谷 2014-01-19 22:07

2014年1月15日讯 /生物谷BIOON/--近日,佐治亚大学研究人员开发出一种新的前体药物,有望减少顺铂所造成的许多负面影响,顺铂一个常用的化疗治疗药物。

顺铂用于治疗多种癌症,但它最常用于膀胱癌,卵巢癌,宫颈癌,睾丸和肺癌治疗。它是一种有效的药物,但它往往会导致患者肾脏、听力和平衡感严重、不可逆的损伤。

乔治亚大学研究人员在一个新的前体药物配方中,阿司匹林组合顺铂,他们称之为铂-A,新的前体药物可以防止顺铂的负面效应。相关研究论文发表在Angewandte Chemie杂志上。

Rakesh Pathak表示:我们知道,炎症在这些副作用的发展中发挥重要作用,通过将阿司匹林与顺铂组合,我们可以帮助控制这种反应,减少对身体的损害。

减少这些负面影响,可以为患者提供更好的生活质量。前体药物如铂-A大多以无效形式进入人体,但他们通过正常的代谢过程后,被转化为活性形式。

这有点像鸡尾酒疗法,Dhar和Pathak警告说,他们的实验结果是初步的,在生物体进行测试前,他们必须做更多的工作。(生物谷Bioon.com)

 

An Activable Prodrug Platin-A for Simultaneous Release of Cisplatin and Aspirin

James E. Hataway

Researchers at the University of Georgia have developed a new prodrug that promises to reduce many of the negative side effects caused by cisplatin, a commonly prescribed chemotherapy treatment.Cisplatin may be used to treat a variety of cancers, but it is most commonly prescribed for cancer of the bladder, ovaries, cervix, testicles and lung. It is an effective drug, but it often causes severe and irreversible damage to a patient's kidneys, hearing and sense of balance.

UGA researchers combined cisplatin with aspirin in a new single prodrug formulation they call Platin-A, which prevents these negative side effects by reducing inflammation. They reported their findings recently in Angewandte Chemie, a journal published by the German Chemical Society."We know that inflammation plays a major role in the development of these side effects," said Rakesh Pathak, lead author of the paper and postdoctoral research associate in the UGA chemistry department. "By attaching aspirin to cisplatin, we can help control this response and reduce damage to the body."

Reducing these negative side effects will not only provide the patient with a better quality of life during and after treatment, but it may also make oncologists less hesitant to prescribe cisplatin.Prodrugs like Platin-A enter the body in a mostly inactive state, but they are converted to their active state after going through normal metabolic processes. Prodrugs allow scientists to have more control over the simultaneous release of both drugs and how long it remains active.

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