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Nature:外伤性脑损伤的治疗方法

  1. 外伤性
  2. 治疗方法
  3. 脑损伤

来源:Nature中文网 2014-01-13 15:24

这项研究描述了一个闭锁性颅骨骨折小鼠模型,其病理与人类轻度外伤性脑损伤相似。

外伤性脑损伤(经常是由交通事故造成的)是一个主要杀手和神经疾病的一个病因。

这项研究描述了一个闭锁性颅骨骨折小鼠模型,其病理与人类轻度外伤性脑损伤相似。

本文作者利用长期活体显微镜方法来研究从受伤开始起的损伤反应动态。他们利用该模型发现,实质细胞和脑膜细胞死亡可以通过“嘌呤能受体”对抗剂和抗氧化剂“谷胱甘肽”进行局部治疗来减少。(生物谷Bioon.com)

生物谷推荐的英文摘要

Nature        doi:10.1038/nature12808

Transcranial amelioration of inflammation and cell death after brain injury

Theodore L. Roth,  Debasis Nayak,  Tatjana Atanasijevic,  Alan P. Koretsky,  Lawrence L. Latour  & Dorian B. McGavern

Traumatic brain injury (TBI) is increasingly appreciated to be highly prevalent and deleterious to neurological function1, 2. At present, no effective treatment options are available, and little is known about the complex cellular response to TBI during its acute phase. To gain insights into TBI pathogenesis, we developed a novel murine closed-skull brain injury model that mirrors some pathological features associated with mild TBI in humans and used long-term intravital microscopy to study the dynamics of the injury response from its inception. Here we demonstrate that acute brain injury induces vascular damage, meningeal cell death, and the generation of reactive oxygen species (ROS) that ultimately breach the glial limitans and promote spread of the injury into the parenchyma. In response, the brain elicits a neuroprotective, purinergic-receptor-dependent inflammatory response characterized by meningeal neutrophil swarming and microglial reconstitution of the damaged glial limitans. We also show that the skull bone is permeable to small-molecular-weight compounds, and use this delivery route to modulate inflammation and therapeutically ameliorate brain injury through transcranial administration of the ROS scavenger, glutathione. Our results shed light on the acute cellular response to TBI and provide a means to locally deliver therapeutic compounds to the site of injury.

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