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PLoS One:发现HIV和HPV双重感染个体患结直肠癌的风险更高

来源:生物谷 2014-01-01 23:50

2014年1月1日 讯 /生物谷BIOON/ --人乳头瘤病毒(HPV)可以引发妇女患宫颈癌,其同时也是引发人类患直肠癌症的元凶;近日,来自加州大学洛杉矶分校护理学院的研究人员通过研究发现,具有男男性行为的老年HIV阳性个体,其患HPV的风险更高,而且HIV和HPV双重感染个体患结直肠癌的风险更高,相关研究刊登于国际杂志PLoS One上。

在HIV感染或未感染老年个体中,吸烟可以增加20%患特殊类型HPV的概率,这项研究也是美国首次开展的研究,主要研究40-69岁有男男性行为的老年个体患HPV的研究报告。

Dorothy J. Wiley教授表示,侵袭性的结直肠癌是同性恋和双性恋的主要健康风险,如今,在男男性行为的HIV感染男性个体中患侵袭性直肠癌的比率已经升高到了70%。这项研究主要对1200多名参与者进行研究,大约49%的男性是HIV阳性感染者,对患者进行半年一次的随访,研究者对所有的男性都进行性别、行为HIV感染特征以及HPV检测情况进行调查统计。

通过分析,结果显示,在所有受访个体中HPV感染的情况非常普遍,而且受HPV影响的40至69岁男性患者数量处于持续增加的状态;然而相比同一个年龄段的未感染HIV的个体来讲,HIV感染者感染HPV的风险更高一些。下一步研究者希望通过更为深入的研究来开发出更为有效的HPV感染干预措施,包括接种疫苗以及筛查手段等。(生物谷Bioon.com)

Factors Affecting the Prevalence of Strongly and Weakly Carcinogenic and Lower-Risk Human Papillomaviruses in Anal Specimens in a Cohort of Men Who Have Sex with Men (MSM)

Dorothy J. Wiley mail, Xiuhong Li, Hilary Hsu, Eric C. Seaberg, Ross D. Cranston, Stephen Young, Gypsyamber D’Souza, Otoniel Martínez-Maza, Katherine DeAzambuja, Kristofer Chua, Shehnaz K. Hussain, Roger Detels

Background MSM are at higher risk for invasive anal cancer. Twelve human papillomaviruses (HPVs) cause cervical cancer in women (Group 1 high-risk HPVs (hrHPVs)) and 13 HPVs are probable/possible causes (Group 2 hrHPVs) of cervical malignancy. HPVs rarely associated with malignancy are classified as lower-risk HPVs (lrHPVs). Materials and Methods Dacron-swab anal-cytology specimens were collected from and data complete for 97% (1262/1296) of Multicenter AIDS Cohort Study (MACS) men tested for HPVs using the Linear Array assay. Multivariate Poisson regression analyses estimated adjusted prevalence ratios for Group 1/2 hrHPVs and lrHPVs, controlling for the effects of age, race, ethnicity, sexual partnerships, smoking; HIV-infection characteristics, treatment, and immune status among HIV-infected men. Results HIV-infected men showed 35–90% higher prevalence of Group 1/2 hrHPVs and lrHPVs than HIV-uninfected men, and higher prevalence of multi-Type, and multiple risk-group infections. CD4+ T-cell count was inversely associated with HPV Group 2 prevalence (p<0.0001). The number of receptive anal intercourse (RAI) partners reported in the 24 months preceding HPV testing predicted higher prevalence of Group 1/2 hrHPVs. Men reporting ≥30 lifetime male sex partners before their first MACS visit and men reporting ≥1 RAI partners during the 24 months before HPV testing showed 17–24% and 13–17% higher prevalence of lrHPVs (p-values ≤0.05). Men reporting smoking between MACS visit 1 and 24 months before HPV testing showed 1.2-fold higher prevalence of Group 2 hrHPVs (p = 0.03). Both complete adherence to CART (p = 0.02) and HIV load <50 copies/mL (p = 0.04) were protective for Group 1 hrHPVs among HIV-infected men. Conclusions HIV-infected men more often show multi-type and multi-group HPV infections HIV-uninfected men. Long-term mutual monogamy and smoking cessation, generally, and CART-adherence that promotes (HIV) viremia control and prevents immunosuppression, specifically among HIV-infected MSM, are important prevention strategies for HPV infections that are relevant to anal cancer.

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