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首页 » Nature报道 » Nat Nanotechnol:标记DNA类分子的碳纳米管可用于癌症治疗

Nat Nanotechnol:标记DNA类分子的碳纳米管可用于癌症治疗

来源:中国科学报 2014-01-01 21:07

碳纳米管和抗体在标记了互补性合成DNA类分子后,可被用来将癌症治疗药物投递至肿瘤所在位置,这是《自然—纳米技术》上一项研究得出的结论。该方法能成功控制小鼠在接受癌症治疗时产生的一些毒性。

碳纳米管非常适合用于药物投递,因为其可以携带大量的治疗药物,而且与小分子一样,能够在循环过程中很快地被肾脏过滤清除掉。

David Scheinberg等人发现单壁碳纳米管能够通过两步法锁定肿瘤目标。首先,经过一小段DNA类似物吗啉寡聚核苷酸(MF)修饰的抗体会预锁定癌细胞;然后,使用经过抗体互补物修饰的纳米管并将其与癌细胞上的抗体结合,通过这种方式将合适的治疗或显影试剂投递至目标肿瘤位置。

研究人员发现碳纳米管能够选择性地与癌细胞发生结合,不论是试管中还是患癌小鼠体内。特别是,他们发现标记了锕225放射性同位素的纳米管能够用于治疗小鼠体内的淋巴瘤,而且能很快被清除掉,从而减少放射性同位素的毒性。(生物谷Bioon.com)

生物谷推荐的英文摘要

Nature Nanotechnology           doi:10.1038/nnano.2013.190

Self-assembly of carbon nanotubes and antibodies on tumours for targeted amplified delivery

J. Justin Mulvey,  Carlos H. Villa,  Michael R. McDevitt,  Freddy E. Escorcia,  Emily Casey  & David A. Scheinberg

Single-walled carbon nanotubes (SWNTs) can deliver imaging agents or drugs to tumours and offer significant advantages over approaches based on antibodies or other nanomaterials. In particular, the nanotubes can carry a substantial amount of cargo (100 times more than a monoclonal antibody), but can still be rapidly eliminated from the circulation by renal filtration, like a small molecule, due to their high aspect ratio. Here we show that SWNTs can target tumours in a two-step approach in which nanotubes modified with morpholino oligonucleotide sequences bind to cancer cells that have been pretargeted with antibodies modified with oligonucleotide strands complementary to those on the nanotubes. The nanotubes can carry fluorophores or radioisotopes, and are shown to selectively bind to cancer cells in vitro and in tumour-bearing xenografted mice. The binding process is also found to lead to antigen capping and internalization of the antibody–nanotube complexes. The nanotube conjugates were labelled with both alpha-particle and gamma-ray emitting isotopes, at high specific activities. Conjugates labelled with alpha-particle-generating 225Ac were found to clear rapidly, thus mitigating radioisotope toxicity, and were shown to be therapeutically effective in vivo.

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