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Mutat Res:极低浓度一氧化碳可阻止辐射旁效应

来源:中国科学报 2013-12-27 14:10

中科院合肥物质科研院医学物理中心的科研人员,在利用极低浓度一氧化碳有效阻止辐射旁效应传递研究方面取得新进展,相关成果近日在线发布于《突变研究》。

辐射旁效应在放疗中的辐射防护方面有着重要的意义。目前的放疗中,对正常组织的防护多采用物理屏蔽的方法,但这仍会导致附近甚至远端的未辐射组织出现类似辐射损伤效应,这可诱发放疗区域外的原发性“二次”癌症发生。

低浓度一氧化碳是近年来新发现的机体内重要信号分子。先前的研究结果发现,14微摩尔每升浓度的一氧化碳可以阻止旁效应导致的遗传物质损伤。目前,国际上已经开展了通过吸入极低浓度一氧化碳,来治疗急性肺损伤、器官移植排异和心血管疾病等方面的临床研究。

在针对癌症发生的两个标志(细胞失控增殖和染色体畸变)的研究中,研究人员发现,低至14微摩尔每升浓度的一氧化碳可通过抑制旁效应细胞间信号分子转化生长因子β1的释放,达到保护未受辐射细胞不会发生癌变的作用。(生物谷Bioon.com)

生物谷推荐的英文摘要

Mutation Research            doi.org/10.1016/j.mrfmmm.2013.11.006

Low concentration of exogenous carbon monoxide protects mammalian cells against proliferation induced by radiation-induced bystander effect

Liping Tonga, K.N. Yub, a, Lingzhi Baoa, Wenqing Wua, Hongzhi Wanga, , Wei Hana

Radiation-induced bystander effect (RIBE) has been proposed to have tight relationship with the irradiation-caused secondary cancers beyond the irradiation-treated area after radiotherapy. Our previous studies demonstrated a protective effect of low concentration carbon monoxide (CO) on the genotoxicity of RIBE after α-particle irradiation. In the present work, a significant inhibitory effect of low-dose exogenous CO, generated by tricarbonyldichlororuthenium (II) dimer [CO-releasing molecule (CORM-2)], on both RIBE-induced proliferation and chromosome aberration was observed. Further studies on the mechanism revealed that the transforming growth factor β1/nitric oxide (NO) signaling pathway, which mediated RIBE signaling transduction, could be modulated by CO involved in the protective effects. Considering the potential of exogenous CO in clinical applications and its protective effect on RIBE, the present work aims to provide a foundation for potential application of CO in radiotherapy.

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