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PNAS:暴露在灰尘中可能防止过敏

来源:EurekAlert 2013-12-17 09:36

一项研究发现,在生命的早期暴露在环境灰尘中可能影响消化道细菌并且获得针对呼吸系统疾病的保护。在婴儿期确立的人类消化道细菌可能影响免疫应答以及哮喘和过敏等疾病的发展。这类疾病的风险减少已经与早期接触狗联系在了一起。

Susan V. Lynch及其同事研究了狗产生的常见家庭尘埃如何影响消化道微生物微生物群以及呼吸道的免疫应答。这组作者报告说,暴露在来自养狗家庭的灰尘中的小鼠在对蟑螂过敏做出应答的时候比没有暴露在这些灰尘中的小鼠产生了较少的呼吸道T细胞和较少的粘液。与狗-尘埃接触的小鼠还比未接触的小鼠拥有一种不同的消化道微生物种群,其中约氏乳酸杆菌(Lactobacillus johnsonii)的含量丰富。这组作者然后让另一组小鼠口服补充了消化道微生物组的约氏乳酸杆菌,然后用蟑螂变应原或呼吸道合胞病毒挑战这些小鼠。补充了微生物的小鼠都拥有对这些攻击的保护,但是与狗-尘埃接触的小鼠比补充了细菌的小鼠拥有更好的保护,这提示约氏乳酸杆是参与呼吸道免疫保护的几种消化道物种之一。

这组作者说,适当的环境微生物暴露可能通过消化道微生物组的调控而提供对呼吸系统的特定保护。(生物谷Bioon.com)

生物谷推荐的英文摘要

Proceedings of the National Academy of the Sciences of the United States of America                doi: 10.1073/pnas.1310750111

House dust exposure mediates gut microbiome Lactobacillus enrichment and airway immune defense against allergens and virus infection

Kei E. Fujimuraa,1, Tine Demoorb,1, Marcus Raucha, Ali A. Faruqia, Sihyug Jangb, Christine C. Johnsonc, Homer A. Bousheyd, Edward Zorattie, Dennis Ownbyf, Nicholas W. Lukacsb,2, and Susan V. Lyncha,2

Exposure to dogs in early infancy has been shown to reduce the risk of childhood allergic disease development, and dog ownership is associated with a distinct house dust microbial exposure. Here, we demonstrate, using murine models, that exposure of mice to dog-associated house dust protects against ovalbumin or cockroach allergen-mediated airway pathology. Protected animals exhibited significant reduction in the total number of airway T cells, down-regulation of Th2-related airway responses, as well as mucin secretion. Following dog-associated dust exposure, the cecal microbiome of protected animals was extensively restructured with significant enrichment of, amongst others, Lactobacillus johnsonii. Supplementation of wild-type animals with L. johnsonii protected them against both airway allergen challenge or infection with respiratory syncytial virus. L. johnsonii-mediated protection was associated with significant reductions in the total number and proportion of activated CD11c+/CD11b+ and CD11c+/CD8+ cells, as well as significantly reduced airway Th2 cytokine expression. Our results reveal that exposure to dog-associated household dust results in protection against airway allergen challenge and a distinct gastrointestinal microbiome composition. Moreover, the study identifies L. johnsonii as a pivotal species within the gastrointestinal tract capable of influencing adaptive immunity at remote mucosal surfaces in a manner that is protective against a variety of respiratory insults.

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