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首页 » BIOON报道 » J Natl Cancer Inst.:肠道微生物组降低与结肠癌有关

J Natl Cancer Inst.:肠道微生物组降低与结肠癌有关

来源:生物谷 2013-12-09 21:05

2013年12月10日讯 /生物谷BIOON/--近期发表在Journal of the National Cancer Institute上的文章称,人类肠道微生物多样性降低与结肠癌相关。

在肠道微生物与结肠癌相关性问题上,基础研究与流行病学研究结论向左。所以该问题还没有一个很明确的结论。

纽约大学公共卫生学院的Jiyoung Ahn博士收集了47位结肠癌病人和94位性别,身高体重指数都与病人相吻合的正常人的排泄物,并从中提取了DNA。接下来科学家对所有的DNA进行测序,确定病人组和对照组的肠道菌群的基因组。结果发现结肠癌患者体内的微生物种类减少。

科学家进一步分析了结肠癌患者的肠道菌群种类。发现梭状芽胞杆菌种类减少,而梭状芽胞杆菌能够将食用纤维降解为丁酸盐,丁酸盐或能预防结肠癌变和炎症反应。同时梭菌属和卟啉单胞菌属细菌增加,这类细菌与口腔和消化道炎症相关。

科学家在论文中总结道,由于肠道菌群多样性可变,我们的发现有助于结肠癌的预防。(生物谷Bioon.com)

doi: 10.1093/jnci/djt300

Human Gut Microbiome and Risk of Colorectal Cancer

Jiyoung Ahn, Rashmi Sinha, Zhiheng Pei, Christine Dominianni, Jing Wu, Jianxin Shi, James J. Goedert, Richard B. Hayes and Liying Yang

We tested the hypothesis that an altered community of gut microbes is associated with risk of colorectal cancer (CRC) in a study of 47 CRC case subjects and 94 control subjects. 16S rRNA genes in fecal bacterial DNA were amplified by universal primers, sequenced by 454 FLX technology, and aligned for taxonomic classification to microbial genomes using the QIIME pipeline. Taxonomic differences were confirmed with quantitative polymerase chain reaction and adjusted for false discovery rate. All statistical tests were two-sided. From 794217 16S rRNA gene sequences, we found that CRC case subjects had decreased overall microbial community diversity (P = .02). In taxonomy-based analyses, lower relative abundance of Clostridia (68.6% vs 77.8%) and increased carriage of Fusobacterium (multivariable odds ratio [OR] = 4.11; 95% confidence interval [CI] = 1.62 to 10.47) and Porphyromonas (OR = 5.17; 95% CI = 1.75 to 15.25) were found in case subjects compared with control subjects. Because of the potentially modifiable nature of the gut bacteria, our findings may have implications for CRC prevention.

 

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