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Probio Antimicrob Prot: 吃糖竟能防蛀牙

来源:中国科学报 2013-12-05 21:04

你的牙科医生可能告诉你,不要吃糖。但是,你也可能通过吃糖与蛀牙作斗争。在一项新研究中,志愿者能通过吃糖果降低唾液中引发蛀牙的细菌水平。

人类牙齿表面存在无数细菌。进餐后,它们会炮制出大量的酸,腐蚀牙釉质。如果不定期进行清洁,这些细菌最终会在牙上腐蚀出一个洞。这里,一类名为变形链球菌的细菌是罪魁祸首。研究人员已经知道,发酵乳中的乳酸菌等“好细菌”能束缚变形链球菌。之前有研究显示,这种细菌封锁能力可以降低老鼠蛀牙数量。

德国生物技术公司ORGANOBALANCE的微生物学家Christine Lang和同事发现,乳酸菌能够减少人类唾液中变形链球菌数量。研究人员测验了60位志愿者唾液中的变形链球菌。然后,一些参与者吃了含有科学家已经用高温杀死乳酸菌的薄荷糖,另一些参与者则吃了无菌薄荷糖。第一轮糖果吃完后,研究人员采集了唾液样本,之后参与者又吃了三块糖,科学家采集了最终样本。

吃含有细菌的薄荷糖的参与者唾液中的变形链球菌较前一天变少,相关研究报告发表于《益生菌和抗菌蛋白》期刊上。当咀嚼这些针对变形链球菌的糖果时,它们能将该细菌从牙齿表面带走。即使科学家杀死了乳酸菌,其表面的糖结构也不会遭到破坏,研究人员推测,该糖结构能钩在自由活动的变形链球菌上,阻止它们回到牙齿上。然后,志愿者能够吞下或吐出这些新的细菌结合体。

研究人员认为,尽管一些坏细菌仍然在嘴里,乳酸菌能够除去足够的变形链球菌,以降低发生蛀牙的风险。“这是考虑细菌的一个完全不同的方式,我们不想杀死它们,只希望移走它们。”Lang说。(生物谷Bioon.com)

生物谷推荐的英文摘要

Probiotics and Antimicrobial Proteins                    doi:10.1007/s12602-013-9148-9

Lactobacillus paracasei DSMZ16671 Reduces Mutans Streptococci: A Short-Term Pilot Study

Caterina Holz, Christiane Alexander, Christina Balcke, Margret Moré, Annegret Auinger, Maren Bauer, Lauren Junker, Jrg Grünwald, Christine Lang, Markus Pompejus

Reducing the burden of pathogenic mutans streptococci is a goal of oral health. Lactobacillus paracasei DSMZ16671, even after heat-killing, specifically co-aggregates mutans streptococci in vitro and retains this activity in human saliva. In rats, it reduces mutans streptococcal colonization of teeth and caries scores. This pilot study sought to assess the potential of heat-killed L. paracasei DSMZ16671 (pro-t-action?) to reduce levels of salivary mutans streptococci in humans, using sugar-free candies as a delivery vehicle. A randomized, placebo-controlled, double-blind in vivo study of three groups examined the short-term effect of sugar-free candies containing 0 (placebo), 1, or 2 mg/candy piece of heat-killed L. paracasei DSMZ16671 on the levels of salivary mutans streptococci determined before and after consumption of the candies. The candies were consumed 4 times during 1.5 consecutive days. Compared to the placebo group, the test groups’ saliva had significantly reduced mutans streptococci as an immediate effect. These results suggest the use of heat-killed L. paracasei DSMZ16671 in suckable candies as a method to reduce mutans streptococci in the mouth and, thereby, caries risk. We think this a new concept and strategy for caries prevention and management.

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