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EHP:揭示两种农药和女性子宫内膜异位症风险增加直接相关

  1. EHP
  2. 农药
  3. 女性
  4. 子宫内膜异位症
  5. 风险

来源:生物谷 2013-12-01 23:20

两种有机氯农药和子宫内膜异位症风险增加直接相关。

2013年12月1日 讯 /生物谷BIOON/ --近日,刊登在国际杂志Environmental Health Perspectives上的一篇研究文章中,来自美国华盛顿西雅图的Fred Hutchinson肿瘤研究中心的研究者通过研究发现,两种有机氯农药和子宫内膜异位症风险增加直接相关,而子宫内膜异位症严重影响着10%的育龄妇女的健康。

文章中,研究人员发现,暴露于β-六六六,六氯环苯和灭蚁灵两种杀虫剂分别可以增加30%和70%患子宫内膜异位症的风险。对于很多女性而言,子宫内膜异位是慢性的,可以严重哦你影响个体的健康和生活质量,由于该疾病是一种雌激素引发的症装,因此研究者也很感兴趣去研究环境中的化合物是否也具有雌激素的特性。

这项研究中,研究者对248名新诊断为子宫内膜异位症的女性进行研究,同时以538名未患病女性为对照进行研究,研究者发现,尽管有机氯农药在美国被严禁使用,但是仍然在这些研究对象的血液中可以检测到,这些有机氯农药严重影响着女性的健康,尤其是育龄女性的身体健康。

实验室研究发现有机氯农药具有雌激素的特性,而且相比对照而言,其也会严重影响个体的生育能力,改变患者的子宫和卵巢的功能,而且会影响女性机体激素的产生。

最后研究者Upson表示,通过研究我们发现有机氯农药可以增加雌激素诱发的疾病的风险比如子宫内膜易位症,研究者希望他们的研究可以给予政策制定者一些建议,使其制定一些可以减少或者消除有机氯农药的政策,从而降低或者阻断其对女性的健康影响。(生物谷Bioon.com)

Organochlorine Pesticides and Risk of Endometriosis: Findings from a Population-Based Case–Control Study

Kristen Upson,1,2 Anneclaire J. De Roos,1, 2 Mary Lou Thompson,3 Sheela Sathyanarayana,4,5,6 Delia Scholes,1,7 Dana Boyd Barr,8 and Victoria L. Holt1,2

Background: Endometriosis is considered an estrogen-dependent disease. Persistent environmental chemicals that exhibit hormonal properties, such as organochlorine pesticides (OCPs), may affect endometriosis risk. Objective: We investigated endometriosis risk in relation to environmental exposure to OCPs. Methods: We conducted the present analyses using data from the Women’s Risk of Endometriosis (WREN) study, a population-based case–control study of endometriosis conducted among 18- to 49-year-old female enrollees of a large health care system in western Washington State. OCP concentrations were measured in sera from surgically confirmed endometriosis cases (n = 248) first diagnosed between 1996 and 2001 and from population-based controls (n = 538). We estimated odds ratios (OR) and 95% CIs using unconditional logistic regression, adjusting for age, reference date year, serum lipids, education, race/ethnicity, smoking, and alcohol intake. Results: Our data suggested increased endometriosis risk associated with serum concentrations of β-hexachlorocyclohexane (HCH) (third vs. lowest quartile: OR = 1.7; 95% CI: 1.0, 2.8; highest vs. lowest quartile OR = 1.3; 95% CI: 0.8, 2.4) and mirex (highest vs. lowest category: OR = 1.5; 95% CI: 1.0, 2.2). The association between serum β-HCH concentrations and endometriosis was stronger in analyses restricting cases to those with ovarian endometriosis (third vs. lowest quartile: OR = 2.5; 95% CI: 1.5, 5.2; highest vs. lowest quartile: OR = 2.5; 95% CI: 1.1, 5.3). Conclusions: In our case–control study of women enrolled in a large health care system in the U.S. Pacific Northwest, serum concentrations of β-HCH and mirex were positively associated with endometriosis. Extensive past use of environmentally persistent OCPs in the United States or present use in other countries may affect the health of reproductive-age women.

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