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Agenus与赛诺菲竞争开发生殖器疱疹疫苗

来源:生物谷 2013-11-13 21:35

2013年11月13日讯 /生物谷BIOON/ --Agenus公司和赛诺菲公司最近都公布了各自研究的生殖器疱疹病毒疫苗研究新进展。Agenus的疫苗HerpV在一项有80人参与的临床研究中表现出良好的效果,使用疫苗的患者病毒水平降低了约15%,通过接触传染的可能也降低了30%。研究人员目前正在分析获得的临床二期数据,估计要到2014年才有可能得到进一步结论。与之相比,赛诺菲与美国国家健康中心的工作则显得落后一步,赛诺菲刚刚宣布启动临床一期研究并招募受试者。(生物谷Bioon.com)

详细英文报道:

Genital herpes is a staggeringly common infection, with an estimated one-in-six Americans aged 14 to 49 carrying the virus. Antivirals are the current treatment, but vaccines from Agenus ($AGEN) and a Sanofi ($SNY), National Institutes of Health (NIH) collaboration are now advancing down the pipeline.

Agenus and the Sanofi-NIH collaboration both gave updates on their clinical candidates this week. The Agenus vaccine, HerpV, is leading the race, having met its primary endpoint in a Phase II trial of 80 subjects, 70 of whom received the treatment. Patients in this treatment arm experienced a 15% reduction in viral shedding--the process that makes herpes transmissible by skin-to-skin contact--and a 34% fall in viral load. The fall was achieved over a 45-day period in patients who received three injections at two-week intervals.

Studies of existing antivirals, such as GlaxoSmithKline's ($GSK) now off-patent Valtrex, have shown an up to 80% fall in viral shedding, but this is only possible when patients take the drug three times a day. Agenus thinks its therapeutic vaccine can improve on this treatment regime, and it expects to present more data from the Phase II trial to support its case in the first half of 2014. Having top-line Phase II data in the bag puts Agenus ahead of the Sanofi-NIH collaboration, which is currently enrolling people in its Phase I study.

The National Institute of Allergy and Infectious Diseases (NIAID) is sponsoring the trial, while Sanofi is listed on ClinicalTrials.gov as a collaborator and is manufacturing the clinical candidate. Success for either vaccine candidate could end the need for daily antiviral doses. "Although genital herpes is treatable, it is a lifelong infection that can exact a substantial psychological and physical toll on infected individuals and places them at higher risk of acquiring HIV. A protective vaccine would help to reduce significantly the spread of this all-too-common sexually transmitted infection," NIAID director Dr. Anthony Fauci said.

 

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