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首页 » BIOON报道 » 研究人员发现一对生物标记物比例可用于预测阿尔兹海默症

研究人员发现一对生物标记物比例可用于预测阿尔兹海默症

来源:生物谷 2013-10-31 21:30

2013年10月31日讯 /生物谷BIOON/ --来自约翰霍普金斯大学的研究人员最近公布了一项长达数年的跟踪研究成果。研究人员通过获得阿尔兹海默症高危人群的脑脊液并分析其中的磷酸化tau淀粉样蛋白体和β淀粉蛋白体的含量发现阿尔兹海默症的发病和这两种生物标记物的比率有直接关系。通过分析数据,研究人员得出结论,当tau淀粉样蛋白体和β淀粉样蛋白体这两中磷酸化的蛋白质比值高时,患者患有阿尔兹海默症的风险就越大。

虽然这其中的原因尚不清楚,但这一结论对及早预测和预防阿尔兹海默症有着很重要意义。(生物谷Bioon.com)

详细英文报道:

Researchers at Johns Hopkins say they've been able to track a pair of biomarkers that can shed light on a patient's risk of developing Alzheimer's and pinpoint the disease before telltale symptoms appear.

Using cerebral spinal fluid tapped from initially healthy but high-risk patients--many with a history of the disease in their families--over a period of 10 years, the Johns Hopkins team found an intriguing correlation between the rise and fall of phosphorylated tau and beta amyloid in the fluid. A particular baseline ratio of the two proteins could be used as a harbinger of mild cognitive impairment, which can be a precursor to Alzheimer's. And the more tau and the less beta amyloid found in the fluid over time could also be predictive of presymptomatic Alzheimer's.

Tau and beta amyloid are already considered the two primary culprits behind Alzheimer's, though there is no solid consensus yet on just what causes the rapid erosion of memory that characterizes the disease, which afflicts millions of people around the world. Gaining insights into biomarkers that can allow investigators to accurately select patients at a very early stage of the disease can be invaluable for companies trying to develop new therapies that can slow or stop disease progression before it does serious damage to the brain.

"When we see patients with high blood pressure and high cholesterol, we don't say we will wait to treat you until you get congestive heart failure. Early treatments keep heart disease patients from getting worse, and it's possible the same may be true for those with presymptomatic Alzheimer's," says Marilyn Albert, a professor of neurology at the Johns Hopkins University School of Medicine. She is the primary investigator of the study, results of which are published in the Oct. 16 issue of the journal Neurology. "But it has been hard to see Alzheimer's disease coming, even though we believe it begins developing in the brain a decade or more before the onset of symptoms.

"We wondered if we could measure something in the cerebral spinal fluid when people are cognitively normal to give us some idea of when they will develop difficulty," Albert adds. "The answer is yes."

 

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