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研究显示流感疫苗能够降低心脏病风险

  1. 心脏病
  2. 流感疫苗

来源:生物谷 2013-10-31 10:45

2013年10月30日讯 /生物谷BIOON/ --七个月前一项研究得出了流感疫苗可以降低心脏病患病风险的结论。这一研究结果遭受了广泛的质疑,原因是该研究项目是由疫苗巨头葛兰素史克赞助的。然而最近一项更独立的研究也呈现出了同样的结果。在这项研究中,科学家在全球范围随机选取了六组实验对象,发现接种流感疫苗的实验组比对照组有更低的心脏病发病机率。

2013年10月30日讯 /生物谷BIOON/ --七个月前一项研究得出了流感疫苗可以降低心脏病患病风险的结论。这一研究结果遭受了广泛的质疑,原因是该研究项目是由疫苗巨头葛兰素史克赞助的。然而最近一项更独立的研究也呈现出了同样的结果。在这项研究中,科学家在全球范围随机选取了六组实验对象,发现接种流感疫苗的实验组比对照组有更低的心脏病发病机率。该研究的领导者Dr. Jacob Udel对这一结果表示高兴,称其能够更好促进疫苗的推广。

虽然这一研究是由加拿大的两家研究机构赞助的,有报道显示Dr. Jacob Udel的一些合作者同样接受了一些疫苗制造企业的资助。因此这一研究还需要更进一步的研究。(生物谷Bioon.com)

详细英文报道:

The discovery of a correlation between the flu vaccine and decreased risk of heart attack was met with skepticism earlier this year, particularly in light of GlaxoSmithKline's ($GSK) financial support of the study. But now, several months later, a new, more definitive analysis has identified the same trend.

Writing in the Journal of the American Medical Association, a global team of researchers reported that their meta-analysis of 6 randomized controlled clinical trials linked flu vaccines to a lower risk of heart attacks and other major cardiovascular events. The association was particularly pronounced among patients that were considered high risk because of their active coronary disease. Among patients who had recently suffered a heart attack, administration of the flu vaccine was associated with a 55% drop in the risk of a further major cardiac event.

In the broader patient population, the use of the vaccine was linked to a 36% fall in the risk of having a heart attack, stroke or other major cardiac event. A causal relationship is yet to be established--and was never one of the goals of the meta-analysis--but the team believe the data are a compelling indication the flu vaccine is having an effect. More work is needed to confirm cause and effect, though. "We would like to do a randomized clinical trial so that a skeptical public can put the issue to rest," lead author Dr. Jacob Udell told HealthDay.

In an accompanying JAMA editorial, PATH's Dr. Kathleen Neuzil dissects the meta-analysis before calling for healthcare professionals to push for 100% vaccination of their communities. For some, the potential to cut the risk of heart attack could prove more compelling than flu prevention. "People who don't like vaccines probably don't like dying from heart attacks either. Maybe this is a good enough reason for the skeptics to go and get their flu shots," Udell told The New York Times.

Udell was funded by two Canadian research institutions, although several of his collaborators report receiving grant funding from Big Pharma companies including AstraZeneca ($AZN), Merck ($MRK) and Sanofi ($SNY).

 


 

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