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首页 » BIOON报道 » Neurology:科学家发现血压药物也可以降低个体患阿尔兹海默氏症的风险

Neurology:科学家发现血压药物也可以降低个体患阿尔兹海默氏症的风险

来源:生物谷 2013-10-18 22:59

2013年10月19日 讯 /生物谷BIOON/ --近日,来自约翰霍普金斯大学研究者领导的一项对3000多个老年个体进行的研究发现,服用特定的血压药物不光可以有效控制血压,而且或许还可以降低由阿尔兹海默氏症(AD)引发的痴呆的风险,相关研究刊登于国际杂志Neurology上。

文章中,研究者表示,超过75岁、认知功能正常的使用利尿药(血管紧张素1受体阻滞剂,ARBs)和血管紧张素转化酶抑制剂(ACE)的老年个体,其患AD风险至少降低50%;另外使用利尿药也会导致个体患轻度认知损伤的风险降低;而β阻断剂和钙拮抗药和风险降低并无关系。

研究者Sevil Yasar表示,发现了这种新型疗法或许对于抑制AD引发的痴呆症非常有帮助,我们的研究也验证了此前的研究发现,即降压药物不光可以控制血压,而且也具有别的用途;这些血压药物不仅可以用于正常认知的个体,而且也可以用于那些轻微认知损伤的个体的治疗。

最后研究者表示,这项研究发现对于未来的研究也很有帮助,比如在使用血压药的同时进行脑部成像,这样也便于研究者更好地理解疾病发生的分子机制以及生化基础,这也为未来识别新型的药物靶点来抑制疾病发生,缓解个体认知能力下降以及AD导致的痴呆症的发生提供一定的依据。(生物谷Bioon.com)

Antihypertensive drugs decrease risk of Alzheimer disease

Sevil Yasar, MD, PhD, Jin Xia, MS, Wenliang Yao, PhD, Curt D. Furberg, MD, PhD, Qian-Li Xue, PhD, Carla I. Mercado, PhD, Annette L. Fitzpatrick, PhD, Linda P. Fried, MD, Claudia H. Kawas, MD, Kaycee M. Sink, MD, Jeff D. Williamson, MD, Steven T. DeKosky, MD, Michelle C. Carlson, PhD; For the Ginkgo Evaluation of Memory (GEM) Study Investigators

Objectives: The aim of this study was to determine whether use of diuretics, angiotensin-1 receptor blockers (ARB), angiotensin-converting enzyme inhibitors (ACE-I), calcium channel blockers (CCB), or β-blockers (BB) was associated with a reduced risk of Alzheimer disease (AD) dementia in participants with normal cognition or mild cognitive impairment (MCI). Methods: Secondary longitudinal data analysis of the Ginkgo Evaluation of Memory Study in older adults at least 75 years of age with normal cognition (n = 1,928) or MCI (n = 320) over a median 6.1-year period using Cox proportional hazard models after adjusting for confounders. Results: Diuretic use was reported by 15.6%, ARB 6.1%, ACE-I 15.1%, CCB 14.8%, and BB 20.5%. Of the 2,248 participants, 290 (13%) developed AD dementia. Hazard ratio for incident AD dementia among participants with normal cognition was 0.51 in diuretic (95% confidence interval [CI] 0.31–0.82), 0.31 in ARB (95% CI 0.14–0.68), 0.50 in ACE-I (95% CI 0.29–0.83), 0.62 in CCB (95% CI 0.35–1.09), and 0.58 in BB (95% CI 0.36–0.93) users and was not significantly altered when mean systolic blood pressure was above 140 mm Hg. In participants with MCI, only diuretic use was associated with decreased risk (hazard ratio = 0.38, 95% CI 0.20–0.73). Conclusions: Diuretic, ARB, and ACE-I use was, in addition to and/or independently of mean systolic blood pressure, associated with reduced risk of AD dementia in participants with normal cognition, while only diuretic use was associated with reduced risk in participants with MCI. GLOSSARY ACE-I= angiotensin-converting enzyme inhibitor; AD= Alzheimer disease; ARB= angiotensin-1 receptor blocker; BB= β-blocker; CCB= calcium channel blocker; CHF= congestive heart failure; CI= confidence interval; DBP= diastolic blood pressure; DM= diabetes mellitus; DSM-IV= Diagnostic and Statistical Manual of Mental Disorders, 4th edition; GEMS= Ginkgo Evaluation of Memory Study; HR= hazard ratio; HTN= hypertension; MCI= mild cognitive impairment; RAS= renin-angiotensin system; SBP= systolic blood pressure

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