新功能、新界面、新体验,扫描即可下载生物谷APP!
首页 » 高血压 » 高血压药物verapamil可能将用于肺结核治疗

高血压药物verapamil可能将用于肺结核治疗

来源:生物谷 2013-09-09 19:56

2013年9月9日讯 /生物谷BIOON/ --约翰霍普金斯大学的研究人员最近发现治疗高血压的药物verapamil可被用于治疗肺结核。Verapamil是一种钙离子通道抑制物药物。在小鼠实验中,研究人员将这种药物和治疗肺结核的常规药物isoniazid 和 rifampin结合使用时,患病小鼠的痊愈时间由之前的6个月缩短到了4个月。研究人员将于今年晚些时候在印度进行临床试验以检验这种综合疗法的效果。(生物谷Bioon.com)

详细英文报道:

By combining a drug used to treat high blood pressure and headaches with the standard, daily antibiotic course of therapy for tuberculosis, scientists may have found a more effective way to combat the contagious lung disease.

In mice, scientists at the Johns Hopkins University School of Medicine tested verapamil, a so-called calcium channel blocker, in combination with the antibiotics isoniazid and rifampin in mice--two common TB drugs. They found that the high blood pressure drug verapamil effectively accelerated treatment of TB. Test animals that received the cocktail were cured of TB in four months instead of the usual 6 months.

After two months of treatment, verapamil accelerated killing of TB bacteria 10-fold. After four months, half of the lung tissue samples from mice receiving verapamil had zero bacterial counts, while all tissue samples in mice not on the blood pressure medication were still positive for TB.

Clinical trials will begin later this year in India, where TB is a huge public health problem.

TB is difficult to treat in part because patients often quit their medication regimen before completing their long courses of treatment and end up developing drug-resistant TB strains. The drug combo tested by the Johns Hopkins team could improve drug adherence and make it easier for infected people to complete their drug therapy as prescribed.

More than 2.2 billion people--a third of the world's population--are infected with Mycobacterium tuberculosis, the deadly bacterium that causes TB. About a million people per year, most of whom live in developing nations, die from TB each year.

 

温馨提示:87%用户都在生物谷APP上阅读,扫描立刻下载! 天天精彩!


相关标签

最新会议 培训班 期刊库