新功能、新界面、新体验,扫描即可下载生物谷APP!
首页 » 帕金森病 » UCSF发现激动素能够应用于治疗帕金森症

UCSF发现激动素能够应用于治疗帕金森症

来源:生物谷 2013-08-20 17:42

2013年8月20日讯 /生物谷BIOON/ --来自加州大学旧金山分校的研究人员发现一种在化妆品中很常见的成分--激动素可能能用于治疗帕金森症。研究人员发现这种化学物质能够通过改变一种名为PINK1酶突变型分泌水平来使趋于死亡的神经细胞恢复正常。PINK1酶突变后无法正常表达而导致神经细胞线粒体损伤进而导致神经细胞死亡并最终引发帕金森症。而激动素能够刺激PINK1突变型分泌正常的PINK1酶从而达到预防和治疗帕金森症的目的。(生物谷Bioon.com)

详细英文报道:

A common ingredient used to fight wrinkles may also have the ability to fight Parkinson's disease. In laboratory tests, University of California, San Francisco (UCSF) researchers found that the chemical, called kinetin, thwarted the death of nerve cells damaged by mutations that cause a hereditary form of Parkinson's.

The scientists used kinetin--a kind of plant hormone that promotes cell division--to increase mutant PINK1 enzyme activity in nerve cells to near normal levels. The PINK1 enzyme plays a role in the disease because PINK1 mutations cause cell malfunctions that trigger some cases of early-onset Parkinson's disease. PINK1 malfunctions impair the cells' mitochondria, the powerhouse that converts food energy into the molecule ATP--the form of chemical energy used by cells.

In lab studies, kinetin also increased enzyme activity beyond normal levels in nerve cells with normal PINK1. The findings suggests that kinetin might also have therapeutic potential in cases of Parkinson's disease that don't involve PINK1 mutations, as a previous study showed that similar heightened levels of PINK1 slowed the development of abnormal movement in fruit flies with a Parkinson's-like disease caused by a different defect. The research appeared Aug. 15 in the journal Cell.

The research is significant because it marks the first time that scientists have achieved highly specific targeting of a kinase--an important class of enymes--to increase rather than to inhibit their activity, UCSF chemist and study author Kevan Shokat said in a university statement.

The researchers think that a similar approach in humans could not only help create a possible new therapy for Parkinson's but also open up new ways to combat other diseases, including diabetes and cancer.

 

温馨提示:87%用户都在生物谷APP上阅读,扫描立刻下载! 天天精彩!


相关标签

最新会议 培训班 期刊库