新功能、新界面、新体验,扫描即可下载生物谷APP!
首页 » BIOON报道 » Gut:剖腹产可降低后代肠道微生物群落的多样性且增加其变态反应的风险

Gut:剖腹产可降低后代肠道微生物群落的多样性且增加其变态反应的风险

来源:生物谷 2013-08-14 00:01

相比顺产的儿童来说,通过剖腹产手术出生的儿童更容易经常发生机体变态反应。

2013年8月13日 讯 /生物谷BIOON/ --近日,刊登在国际杂志Gut上一篇研究报告中,来自瑞典和苏格兰的研究者通过研究发现,相比顺产的儿童来说,通过剖腹产手术出生的儿童更容易经常发生机体变态反应,这或许是因为这些儿童肠道中的微生物菌群多样性较低而导致的。

这项研究中,研究者对年龄段从0-2岁的24名儿童的肠道菌群的发育进行研究,其中9名儿童通过剖腹产出生,而其它15名顺产出生;研究者使用分子生物学的分析手段对这些儿童肠道中存在的多样性细菌进行了全面的分析。结果发现,那些通过剖腹产手术出生的儿童期在其出生两年的时间里,其肠道中微生物菌群的多样性较低,尤其是拟杆菌类细菌比较低,而且这些儿童发生变态反应的风险较高。

研究者Maria Jenmalm表示,有时候进行剖腹产手术非常有必要,但是这明显会影响到出生后代的机体健康。肠道细菌菌群或许被认为是人体最大的器官,在成年人的大肠和小肠中的细菌数量至少是机体其它部位的十倍以上。

这项研究中研究者使用了先进的DNA测序技术以及计算机分析方法,通过研究研究者发现,通过剖腹产手术剩下的小孩儿,其机体的微生物种群多样性会明显降低,而且这些儿童患机体变态反应的风险也相应增加,于此同时研究者还表示,他们还可以在同一时间对成千上百份机体样品中的微生物组分进行鉴别,而且同时也可以对这些微生物群落的特性进行分析鉴别。(生物谷Bioon.com)

Onecut1 Is Essential for Horizontal Cell Genesis and Retinal Integrity

Fuguo Wu1,2,3, Renzhong Li1,2,3, Yumiko Umino3,5, Tadeusz J. Kaczynski1,2,3, Darshan Sapkota1,2,3, Shengguo Li6, Mengqing Xiang6, Steven J. Fliesler1,3,7, David M. Sherry8, Maureen Gannon9, Eduardo Solessio3,5, and Xiuqian Mu1,2,3,4

Horizontal cells are interneurons that synapse with photoreceptors in the outer retina. Their genesis during development is subject to regulation by transcription factors in a hierarchical manner. Previously, we showed that Onecut 1 (Oc1), an atypical homeodomain transcription factor, is expressed in developing horizontal cells (HCs) and retinal ganglion cells (RGCs) in the mouse retina. Herein, by knocking out Oc1 specifically in the developing retina, we show that the majority (∼80%) of HCs fail to form during early retinal development, implying that Oc1 is essential for HC genesis. However, no other retinal cell types, including RGCs, were affected in the Oc1 knock-out. Analysis of the genetic relationship between Oc1 and other transcription factor genes required for HC development revealed that Oc1 functions downstream of FoxN4, in parallel with Ptf1a, but upstream of Lim1 and Prox1. By in utero electroporation, we found that Oc1 and Ptf1a together are not only essential, but also sufficient for determination of HC fate. In addition, the synaptic connections in the outer plexiform layer are defective in Oc1-null mice, and photoreceptors undergo age-dependent degeneration, indicating that HCs are not only an integral part of the retinal circuitry, but also are essential for the survival of photoreceptors. In sum, these results demonstrate that Oc1 is a critical determinant of HC fate, and reveal that HCs are essential for photoreceptor viability, retinal integrity, and normal visual function.

温馨提示:87%用户都在生物谷APP上阅读,扫描立刻下载! 天天精彩!


相关标签

最新会议 培训班 期刊库